{"description":"Adverse events and all-cause mortality were assessed in the safety population of patients who received at least one dose of study treatment. Compared to the participant flow numbers, there are two patients less in the Module 1 safety population as they did not receive any study treatment.","eventGroups":[{"deathsNumAffected":10,"deathsNumAtRisk":13,"description":"This Module is designed to evaluate the tolerability and the overall safety profile of NUC-3373 (1875 mg/m2) + LV (400 mg/m2) + pembrolizumab (200 mg) in the treatment of patients with advanced solid tumours (dose validation phase).\n\nNUC-3373 and LV will be administered on Days 1, 8 and 15 and pembrolizumab will be administered on Day 1 of 21-day cycles. The dosing schedule may be adjusted based on emerging data with agreement from the Safety Review Committee. Following completion of the dose validation phase, expansion cohorts may be initiated at the selected dose level.","id":"EG000","otherNumAffected":13,"otherNumAtRisk":13,"seriousNumAffected":7,"seriousNumAtRisk":13,"title":"Module 1 (NUC-3373 + LV + Pembrolizumab)"},{"deathsNumAffected":3,"deathsNumAtRisk":4,"description":"This Module is designed to assess NUC-3373 (750 mg/m2) + LV (400 mg/m2) + docetaxel (55 mg/m2) for the treatment of patients with advanced/metastatic NSCLC or pleural mesothelioma who have progressed on, or were unable to tolerate, 1 or 2 prior lines of cytotoxic chemotherapy-containing regimens for advanced/metastatic disease (dose validation phase).\n\nNUC-3373 and LV will be administered on Days 1 and 22 and docetaxel will be administered on Day 8 of 28-day cycles. The dosing schedule may be adjusted based on emerging data with agreement from the Safety Review Committee. Following completion of the dose validation phase, expansion cohorts may be initiated at the selected dose level.","id":"EG001","otherNumAffected":4,"otherNumAtRisk":4,"seriousNumAffected":3,"seriousNumAtRisk":4,"title":"Module 2 (NUC-3373 + LV + Docetaxel)"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":9,"numAtRisk":13,"numEvents":20},{"groupId":"EG001","numAffected":1,"numAtRisk":4,"numEvents":4}],"term":"Vomiting"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":7,"numAtRisk":13,"numEvents":16},{"groupId":"EG001","numAffected":2,"numAtRisk":4,"numEvents":8}],"term":"Diarrhea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 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