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msec"},{"categories":[{"measurements":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"307"},{"groupId":"OG001","value":"301"}],"units":"Participants"}],"title":"QTcF interval increase from baseline > 60 msec"}],"denoms":[{"counts":[{"groupId":"OG000","value":"309"},{"groupId":"OG001","value":"301"}],"units":"Participants"}],"description":"Twelve lead ECGs were collected using an automated ECG machine that calculated heart rate and measured corrected QT (QTc interval, QT interval, PR interval and QRS complex). Criteria for heart rate was as follows, \\<= 50 beats/minute (min), \\>=100 beats/min, increase from baseline \\>= 20 beats/min, decrease from baseline \\>= 20 beats/min. Criteria for PR interval was \\>= 220 millisecond (msec). Criteria for QRS interval was \\>= 120 msec. Criteria for QT interval was as follows, \\<=450 msec, \\> 450 to \\<= 480 msec, \\>480 to \\<=500 msec, \\>500 msec, increase from baseline \\<= 30 msec, increase from baseline \\> 30 to \\<= 60 msec. Criteria for QTCF interval was as follows, \\<=450 msec, \\> 450 to \\<= 480 msec, \\> 480 to \\<= 500 msec, \\> 500 msec, increase from baseline \\<= 30 msec, increase from baseline \\> 30 to \\<= 60 msec, increase from baseline \\> 60 msec. Baseline was defined as the last assessment on or prior to the date of the first dose of study treatment.","groups":[{"description":"Participants were randomized to receive vepdegestrant 200 milligrams (mg) orally, once daily on Days 1 to 28 of each 28-day cycle. Participants continued to receive assigned treatment until objective disease progression, unacceptable toxicity, death, participant refused further treatment, or one of the other reasons for treatment discontinuation per protocol was met.","id":"OG000","title":"Vepdegestrant (ARV-471)"},{"description":"Participants were randomized to receive fulvestrant 500 mg, intramuscularly (injection) on Days 1 and 15 of Cycle 1 and then on Day 1 of each cycle starting from Cycle 2 Day 1, where 1 cycle = 28 days. Participants continued to receive assigned treatment until objective disease progression, unacceptable toxicity, death, participant refused further treatment, or one of the other reasons for treatment discontinuation per protocol was met.","id":"OG001","title":"Fulvestrant"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"SAS included all randomized participants who received at least 1 dose of study treatment. Here, \"Overall Number of Participants Analyzed\" signifies participants evaluable for this outcome measure. Here, \"Number Analyzed\" signifies participants evaluable for this outcome measure","reportingStatus":"POSTED","timeFrame":"From baseline up to 28 days after last dose of study treatment (up to 19.56 months and 20.38 months for vepdegestrant and fulvestrant arms respectively)","title":"Number of Participants According to Categorization of Electrocardiogram (ECG) Parameters","type":"SECONDARY","unitOfMeasure":"Participants"}