{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.83","upperLimit":"2.98","value":"1.83"},{"groupId":"OG001","lowerLimit":"1.00","upperLimit":"3.88","value":"2.00"},{"groupId":"OG002","lowerLimit":"0.83","upperLimit":"3.88","value":"1.97"},{"groupId":"OG003","lowerLimit":"1.02","upperLimit":"2.95","value":"2.47"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"28"},{"groupId":"OG003","value":"4"}],"units":"Participants"}],"title":"Cycle 1 Day 1: Selumetinib"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.83","upperLimit":"2.98","value":"1.83"},{"groupId":"OG001","lowerLimit":"1.00","upperLimit":"5.87","value":"2.02"},{"groupId":"OG002","lowerLimit":"0.83","upperLimit":"5.87","value":"2.00"},{"groupId":"OG003","lowerLimit":"1.02","upperLimit":"2.95","value":"2.47"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"28"},{"groupId":"OG003","value":"4"}],"units":"Participants"}],"title":"Cycle 1 Day 1: N-desmethyl selumetinib"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.92","upperLimit":"4.07","value":"2.00"},{"groupId":"OG001","lowerLimit":"0.92","upperLimit":"4.05","value":"1.97"},{"groupId":"OG002","lowerLimit":"0.92","upperLimit":"4.07","value":"2.00"},{"groupId":"OG003","lowerLimit":"0.97","upperLimit":"2.00","value":"1.05"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"29"},{"groupId":"OG003","value":"4"}],"units":"Participants"}],"title":"Cycle 2 Day 1: Selumetinib"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.92","upperLimit":"4.07","value":"2.00"},{"groupId":"OG001","lowerLimit":"0.92","upperLimit":"4.05","value":"2.01"},{"groupId":"OG002","lowerLimit":"0.92","upperLimit":"4.07","value":"2.00"},{"groupId":"OG003","lowerLimit":"0.98","upperLimit":"2.00","value":"1.56"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"29"},{"groupId":"OG003","value":"4"}],"units":"Participants"}],"title":"Cycle 2 Day 1: N-desmethyl selumetinib"}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"32"},{"groupId":"OG003","value":"4"}],"units":"Participants"}],"description":"To further evaluate the PK of the granule formulation.","dispersionType":"Full Range","groups":[{"description":"Global Cohort 1 (\\>=4 to \\<7 years)","id":"OG000","title":"Global Cohort 1"},{"description":"Global Cohort 2 (\\>=1 to \\<4 years)","id":"OG001","title":"Global Cohort 2"},{"description":"Global Cohorts (\\>=1 to \\<7 years)","id":"OG002","title":"Total in Global"},{"description":"Japan Cohort (\\>=1 to \\<7 years)","id":"OG003","title":"Japan Cohort"}],"paramType":"MEDIAN","populationDescription":"Pharmacokinetic analysis set was used for analysis. Some records were excluded for given visits and analytes due to missing concentration data, issues taking the medication and usage of prohibited medications.","reportingStatus":"POSTED","timeFrame":"Pre-dose and 1, 2, 3, 4, 6, 8, 10-12 and 18-24 hours after selumetinib single dose on the first day of study treatment (Cycle 1 Day 1). Pre-dose, 1, 2, 3, 4, 6, 8, and 10-12 hours post-dose on Cycle 2 Day 1 (each cycle is 28 days)","title":"Selumetinib and N-desmethyl Selumetinib Tmax Derived After Single and Multiple Dose Administration","type":"SECONDARY","unitOfMeasure":"h"}