{"classes":[{"categories":[{"measurements":[{"comment":"Values listed as \"Not Detected (ND)\" or \"Below the Limit of Quantitation (BLOQ)\" could not be quantified by the qPCR assay and are therefore reported as NA.","groupId":"OG000","value":"NA"},{"comment":"Values listed as \"Not Detected (ND)\" or \"Below the Limit of Quantitation (BLOQ)\" could not be quantified by the qPCR assay and are therefore reported as NA.","groupId":"OG001","lowerLimit":"0","upperLimit":"0","value":"NA"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Baseline (1 week prior to infusion)"},{"categories":[{"measurements":[{"comment":"Values listed as \"Not Detected (ND)\" or \"Below the Limit of Quantitation (BLOQ)\" could not be quantified by the qPCR assay and are therefore reported as NA.","groupId":"OG000","value":"NA"},{"comment":"Values listed as \"Not Detected (ND)\" or \"Below the Limit of Quantitation (BLOQ)\" could not be quantified by the qPCR assay and are therefore reported as NA.","groupId":"OG001","lowerLimit":"0","upperLimit":"0","value":"NA"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Predose Day 0"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4,240,000"},{"groupId":"OG001","lowerLimit":"779,000","upperLimit":"3,970,000","value":"2,570,000"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Post Dose Day 0"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3,190,000"},{"groupId":"OG001","lowerLimit":"20,700","upperLimit":"1,710,000","value":"59,200"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2,640,000"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"2,270,000","value":"408,000"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Day 2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3,500,000"},{"groupId":"OG001","lowerLimit":"18,700","upperLimit":"3,400,000","value":"570,000"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"743,000"},{"groupId":"OG001","lowerLimit":"5,320","upperLimit":"3,730,000","value":"101,000"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Day 7"},{"categories":[{"measurements":[{"groupId":"OG000","value":"674,000"},{"groupId":"OG001","lowerLimit":"14,200","upperLimit":"961,000","value":"112,000"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Day 10"},{"categories":[{"measurements":[{"groupId":"OG000","value":"984,000"},{"groupId":"OG001","lowerLimit":"7,900","upperLimit":"938,000","value":"112,000"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Day 14"},{"categories":[{"measurements":[{"groupId":"OG000","value":"504,000"},{"groupId":"OG001","lowerLimit":"1,140","upperLimit":"489,000","value":"41,300"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Day 21"},{"categories":[{"measurements":[{"groupId":"OG000","value":"404,000"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"297,000","value":"32,100"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Day 28"},{"categories":[{"measurements":[{"groupId":"OG000","value":"197,000"},{"groupId":"OG001","lowerLimit":"0","upperLimit":"203,000","value":"27,800"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Week 6"},{"categories":[{"measurements":[{"groupId":"OG000","value":"163,000"},{"groupId":"OG001","lowerLimit":"1,960","upperLimit":"121,000","value":"27,200"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Week 12"},{"categories":[{"measurements":[{"groupId":"OG001","value":"42,400"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Month 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"88,100"},{"groupId":"OG001","value":"8,120"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Month 6"},{"categories":[{"measurements":[{"comment":"Values listed as \"Not Detected (ND)\" or \"Below the Limit of Quantitation (BLOQ)\" could not be quantified by the qPCR assay and are therefore reported as NA.","groupId":"OG001","value":"NA"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Month 15"},{"categories":[{"measurements":[{"comment":"Values listed as \"Not Detected (ND)\" or \"Below the Limit of Quantitation (BLOQ)\" could not be quantified by the qPCR assay and are therefore reported as NA.","groupId":"OG001","value":"NA"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Month 18"}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"description":"Persistence of TCR-T cells in peripheral blood was assessed by quantitative PCR for vector copy number per 1 × 10⁶ cells at baseline (1 week prior to infusion), predose (Day 0), and multiple post-infusion time points through Month 18. Only quantifiable values are summarized. Samples with \"Not Detected (ND)\" or \"Below the Limit of Quantitation (BLOQ)\" are reported as NA and excluded from summary statistics.","dispersionType":"Full Range","groups":[{"description":"Participants received a single intravenous infusion of autologous TCR-T cells manufactured at Dose Level 1 (target 5 (1 to \\<10) × 10⁹ TCR+ cells) following apheresis and manufacturing per protocol. This represents the lowest dose cohort in the sequential dose-escalation design.","id":"OG000","title":"Assigned Dose Level 1 (Target 5 × 10⁹ TCR+ Cells)"},{"description":"Participants received a single intravenous infusion of autologous TCR-T cells manufactured at Dose Level 2 (target 40 (10 to \\<70) × 10⁹ TCR+ cells) following apheresis and manufacturing per protocol. This represents the intermediate dose cohort in the sequential dose-escalation design.","id":"OG001","title":"Assigned Dose Level 2 (Target 40 × 10⁹ TCR+ Cells)"},{"description":"Participants received a single intravenous infusion of autologous TCR-T cells manufactured at Dose Level 3 (target 100 (70 to 100) × 10⁹ TCR+ cells) following apheresis and manufacturing per protocol. This represents the highest dose cohort in the sequential dose-escalation design.","id":"OG002","title":"Assigned Dose Level 3 (Target 100 × 10⁹ TCR+ Cells)"}],"paramType":"MEDIAN","populationDescription":"Persistence analyses included the 8 participants who received TCR-T infusion (1 at Dose Level 1 and 7 at Dose Level 2). A total of 14 participants underwent apheresis, but only infused participants were evaluable for persistence. Samples with \"Not Detected (ND)\" or \"Below the Limit of Quantitation (BLOQ)\" were not quantifiable and are reported as NA. Participants without samples at a given time point were excluded.","reportingStatus":"POSTED","timeFrame":"Baseline through Month 18 post-infusion.","title":"TCR-T Cell Persistence","type":"SECONDARY","unitOfMeasure":"copies/1x10^6 cells"}