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Participants received study treatment until unacceptable toxicity, disease progression, withdrawal of consent, or study closure.","id":"EG000","otherNumAffected":323,"otherNumAtRisk":326,"seriousNumAffected":55,"seriousNumAtRisk":326,"title":"Tucatinib + Trastuzumab + Pertuzumab"},{"deathsNumAffected":33,"deathsNumAtRisk":328,"description":"Participants with locally advanced HER2+/mBC were allocated to receive placebo PO BID, and trastuzumab 6 mg/kg IV or SC at a fixed dose of 600 mg, every 21 days, and pertuzumab 420 mg IV, every 21 days. Participants may also have received a fixed dose combination of 600 mg pertuzumab, 600 mg trastuzumab, and 20,000 units hyaluronidase SC, once every 21 days. 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