{"analyses":[{"ciLowerLimit":"1.4","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"5.2","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.0007","pValueComment":"Model included treatment+visit+treatment by visit interaction+stratification factor for region (U.S. versus non-U.S.) and tumor location (lower limb/all other) based on IRT+PROMIS-PF baseline value.","paramType":"LS Mean Difference","paramValue":"3.3","statisticalMethod":"Mixed model repeated measures"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.96","value":"4.6"},{"groupId":"OG001","spread":"0.88","value":"1.3"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"63"},{"groupId":"OG001","value":"30"}],"units":"Participants"}],"description":"All participants were asked 15 questions from the PROMIS-PF item bank. The questions used one of two 5-point verbal rating scales: either 1 = \"unable to do\", 2 = \"with much difficulty\", 3 = \"with some difficulty\", 4 = \"with a little difficulty\", and 5 = \"without any difficulty\"; or 1 = \"cannot do\", 2 = \"quite a lot\", 3 = \"somewhat\", 4 = \"very little\", and 5 = \"not at all.\" Total scores were converted to T-scores that ranged from 0 to 100, with higher scores representing less physical function interference and better health outcomes.","dispersionType":"Standard Error","groups":[{"description":"Participants received 30 mg BIW vimseltinib for 24 weeks.","id":"OG000","title":"Vimseltinib"},{"description":"Participants received matching placebo BIW for 24 weeks.","id":"OG001","title":"Placebo"}],"paramType":"LEAST_SQUARES_MEAN","populationDescription":"The ITT Set consisted of participants who were randomized to a study treatment regimen. Here, \"Overall Number of Participants Analyzed\" is the number of participants evaluable for this outcome measure at the specified time point.","reportingStatus":"POSTED","timeFrame":"Baseline to Week 25 (Cycle 7, Day 1)","title":"Change From Baseline in the Patient-reported Outcomes Measurement Information System (PROMIS) Physical Function (PF) Score at Week 25","type":"SECONDARY","unitOfMeasure":"score on a scale"}