{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.5","value":"653.2"},{"groupId":"OG001","spread":"101.6","value":"1483.4"},{"groupId":"OG002","spread":"13.7","value":"2252.7"},{"groupId":"OG003","spread":"74.6","value":"5592.0"},{"groupId":"OG004","spread":"30.8","value":"6427.1"},{"groupId":"OG005","spread":"11.1","value":"9919.2"},{"groupId":"OG006","spread":"15.3","value":"15766.7"},{"groupId":"OG007","spread":"45.4","value":"22918.9"},{"groupId":"OG008","spread":"31.7","value":"34948.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"6"},{"groupId":"OG006","value":"5"},{"groupId":"OG007","value":"17"},{"groupId":"OG008","value":"8"}],"units":"Participants"}],"title":"Cycle 1, Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.5","value":"528.6"},{"comment":"Only one participant had measurements at this timepoint.","groupId":"OG001","spread":"NA","value":"2596.4"},{"groupId":"OG002","spread":"42.4","value":"2511.2"},{"groupId":"OG003","spread":"26.4","value":"4259.1"},{"groupId":"OG004","spread":"31.8","value":"6280.1"},{"groupId":"OG005","spread":"16.4","value":"8944.0"},{"groupId":"OG006","spread":"13.9","value":"14624.8"},{"groupId":"OG007","spread":"27.0","value":"18088.1"},{"groupId":"OG008","spread":"96.2","value":"38084.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"5"},{"groupId":"OG005","value":"6"},{"groupId":"OG006","value":"5"},{"groupId":"OG007","value":"15"},{"groupId":"OG008","value":"5"}],"units":"Participants"}],"title":"Cycle 1, Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"2.9","value":"532.2"},{"groupId":"OG001","spread":"68.2","value":"1506.8"},{"groupId":"OG002","spread":"12.1","value":"2485.0"},{"groupId":"OG003","spread":"80.4","value":"6536.5"},{"groupId":"OG004","spread":"21.6","value":"7030.0"},{"groupId":"OG005","spread":"18.0","value":"10171.0"},{"groupId":"OG006","spread":"36.2","value":"20581.5"},{"groupId":"OG007","spread":"57.6","value":"20847.3"},{"groupId":"OG008","spread":"92.3","value":"48172.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"5"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"4"},{"groupId":"OG007","value":"10"},{"groupId":"OG008","value":"3"}],"units":"Participants"}],"title":"Cycle 2, Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.8","value":"568.6"},{"groupId":"OG001","spread":"78.3","value":"1304.5"},{"groupId":"OG002","spread":"22.7","value":"2126.4"},{"groupId":"OG003","spread":"53.6","value":"5135.9"},{"groupId":"OG004","spread":"28.2","value":"6246.6"},{"groupId":"OG005","spread":"23.2","value":"8958.0"},{"groupId":"OG006","spread":"16.0","value":"17093.8"},{"groupId":"OG007","spread":"31.7","value":"22390.0"},{"comment":"Only one participant had measurements at this timepoint.","groupId":"OG008","spread":"NA","value":"37991.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"4"},{"groupId":"OG007","value":"5"},{"groupId":"OG008","value":"1"}],"units":"Participants"}],"title":"Cycle 2, Day 15"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"6"},{"groupId":"OG006","value":"5"},{"groupId":"OG007","value":"17"},{"groupId":"OG008","value":"8"}],"units":"Participants"}],"description":"This is the area under the curve (AUC) from predose through postdose observed after administration of KZR-261 in Cycle 1 (Days 1 and 15) and Cycle 2 (Days 1 and 15). The PK parameters were calculated using all timepoints at which the concentration was measured, ie. predose, 15 minutes post start of infusion, end of infusion, and 5, 15, 30 minutes, 1, 2, 4, 6, and 24 hours post infusion.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants received 1.8 mg/m\\^2 of KZR-261.","id":"OG000","title":"Dose 1"},{"description":"Participants received 3.6 mg/m\\^2 of KZR-261.","id":"OG001","title":"Dose 2"},{"description":"Participants received 7.2 mg/m\\^2 of KZR-261.","id":"OG002","title":"Dose 3"},{"description":"Participants received 12 mg/m\\^2 of KZR-261.","id":"OG003","title":"Dose 4"},{"description":"Participants received 18 mg/m\\^2 of KZR-261.","id":"OG004","title":"Dose 5"},{"description":"Participants received 27 mg/m\\^2 of KZR-261.","id":"OG005","title":"Dose 6"},{"description":"Participants received 40 mg/m\\^2 of KZR-261.","id":"OG006","title":"Dose 7"},{"description":"Participants received 60 mg/m\\^2 of KZR-261.","id":"OG007","title":"Dose 8"},{"description":"Participants received 80 mg/m\\^2 of KZR-261.","id":"OG008","title":"Dose 9"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"The PK analyses were performed for all subjects in the PK population (all subjects that received at least one dose plasma KZR-261 concentration measurement during Cycles 1 and 2 of treatment).","reportingStatus":"POSTED","timeFrame":"Cycle 1: Day 1, Cycle 1: Day 15, Cycle 2: Day 1, and Cycle 2: Day 15","title":"The Plasma Concentration Time Curve of KZR-261 (Part 1)","type":"PRIMARY","unitOfMeasure":"hr*ng/mL"}