{"description":"SAEs \\& Other AEs:safety set-randomized participants who had at least 1 dose of study drug. All-cause mortality:FAS-all randomized participants, classified per assigned drug regardless of actual drug received. As per statistical analysis, Arm A AE planned to be collected and analyzed as single arm regardless of regimen LACP/ACP-L received. Since extension cohort is ongoing and its data collection and analysis was not planned for primary analysis, AE data will be reported after study completion.","eventGroups":[{"deathsNumAffected":69,"deathsNumAtRisk":263,"description":"LACP dosing (study start until 6 November 2022): Participants received Lazertinib 240 milligrams (mg) orally on Day 1 of each subsequent cycle, starting with Cycle 3, along with Amivantamab 1400 mg (1750 mg if body weight greater than or equal to \\[\\>=80\\] kilograms \\[kg\\]) on Cycle 1 Days 1, 2, 8, and 15, and Cycle 2 Day 1 and 1750 mg (2100 mg if body weight \\>=80 kg). Participant also received Pemetrexed 500 mg per square meter (mg/m\\^2) on Day 1 21-day cycle, in combination with carboplatin 750 mg as IV infusion starting on Cycle 1 Day 1 for 4 cycles. From cycle 5 onwards, participants received Amivantamab, Pemetrexed and Lazertinib IV infusions at same dose, as maintenance until disease progression. ACP-L dosing (from 7 November 2022 until study completion): Participants received Amivantamab 1400 mg (1750 mg if body weight \\>=80\\] kg) on Cycle 1 Days 1,2, 8, and 15, and Cycle 2 Day 1 and 1750 mg (2100 mg if body weight \\>=80 kg). Participant also received Pemetrexed 500 mg/m\\^2 on Day 1 of each 21-day cycle, in combination with carboplatin 750 mg as IV infusion starting on Cycle 1 Day 1 for 4 cycles. Lazertinib 240 mg in ACP-L started on Cycle 5 Day 1 or sooner if carboplatin is discontinued before cycle 4. From cycle 5 onwards, participants received Amivantamab, Pemetrexed and Lazertinib IV infusions at same dose, as maintenance until disease progression. Each cycle consists of 21 days.","id":"EG000","otherNumAffected":261,"otherNumAtRisk":263,"seriousNumAffected":137,"seriousNumAtRisk":263,"title":"Main Study: Arm A: Lazertinib + Amivantamab + Carboplatin + Pemetrexed (LACP/ACP-L)"},{"deathsNumAffected":65,"deathsNumAtRisk":263,"description":"Participants received Pemetrexed 500 mg/m\\^2 IV infusion and carboplatin 750 mg IV infusion from Day 1 of Cycle 1 to 4. From cycle 5 onwards, participants received Pemetrexed 500 mg/m\\^2 IV infusion, as maintenance until disease progression. Each cycle consists of 21 days.","id":"EG001","otherNumAffected":222,"otherNumAtRisk":243,"seriousNumAffected":49,"seriousNumAtRisk":243,"title":"Main Study: Arm B: Carboplatin + Pemetrexed (CP)"},{"deathsNumAffected":27,"deathsNumAtRisk":131,"description":"Participants received Amivantamab 1400 mg (1750 mg if body weight \\>=80 kg) on Cycle 1 Days 1,2, 8, and 15, and Cycle 2 Day 1 and 1750 mg (2100 mg if body weight \\>=80 kg) on Day 1 of each cycle, starting with Cycle 3. Participants also received Pemetrexed 500 mg/m\\^2 on Day 1 of each 21-day cycle, in combination with carboplatin 750 mg as IV infusion starting on Cycle 1 Day 1 for 4 cycles. From cycle 5 onwards, participants received Amivantamab and Pemetrexed IV infusions at same dose, as maintenance until disease progression. Each cycle consists of 21 days.","id":"EG002","otherNumAffected":129,"otherNumAtRisk":130,"seriousNumAffected":42,"seriousNumAtRisk":130,"title":"Main Study: Arm C: Amivantamab + Carboplatin + Pemetrexed (ACP)"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA Version 25.0","stats":[{"groupId":"EG000","numAffected":130,"numAtRisk":263},{"groupId":"EG001","numAffected":90,"numAtRisk":243},{"groupId":"EG002","numAffected":58,"numAtRisk":130}],"term":"Nausea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA Version 25.0","stats":[{"groupId":"EG000","numAffected":96,"numAtRisk":263},{"groupId":"EG001","numAffected":72,"numAtRisk":243},{"groupId":"EG002","numAffected":50,"numAtRisk":130}],"term":"Constipation"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA Version 25.0","stats":[{"groupId":"EG000","numAffected":120,"numAtRisk":263},{"groupId":"EG001","numAffected":21,"numAtRisk":243},{"groupId":"EG002","numAffected":41,"numAtRisk":130}],"term":"Stomatitis"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA Version 25.0","stats":[{"groupId":"EG000","numAffected":75,"numAtRisk":263},{"groupId":"EG001","numAffected":42,"numAtRisk":243},{"groupId":"EG002","numAffected":31,"numAtRisk":130}],"term":"Vomiting"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA Version 25.0","stats":[{"groupId":"EG000","numAffected":66,"numAtRisk":263},{"groupId":"EG001","numAffected":16,"numAtRisk":243},{"groupId":"EG002","numAffected":17,"numAtRisk":130}],"term":"Diarrhoea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA Version 25.0","stats":[{"groupId":"EG000","numAffected":13,"numAtRisk":263},{"groupId":"EG001","numAffected":6,"numAtRisk":243},{"groupId":"EG002","numAffected":7,"numAtRisk":130}],"term":"Abdominal Pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA Version 25.0","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":263},{"groupId":"EG001","numAffected":1,"numAtRisk":243},{"groupId":"EG002","numAffected":7,"numAtRisk":130}],"term":"Dry Mouth"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA Version 25.0","stats":[{"groupId":"EG000","numAffected":22,"numAtRisk":263},{"groupId":"EG001","numAffected":1,"numAtRisk":243},{"groupId":"EG002","numAffected":7,"numAtRisk":130}],"term":"Haemorrhoids"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA Version 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