{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.00","value":"0.00"},{"groupId":"OG001","spread":"0.00","value":"0.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"25"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day -3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.00","value":"0.00"},{"groupId":"OG001","spread":"0.00","value":"0.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day -2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.20","value":"0.04"},{"groupId":"OG001","spread":"0.41","value":"0.08"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day -1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.43","value":"0.12"},{"groupId":"OG001","spread":"0.62","value":"0.29"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 0"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.60","value":"0.27"},{"groupId":"OG001","spread":"0.62","value":"0.29"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.69","value":"0.35"},{"groupId":"OG001","spread":"0.82","value":"0.63"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.46","value":"0.15"},{"groupId":"OG001","spread":"0.83","value":"0.50"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.46","value":"0.15"},{"groupId":"OG001","spread":"0.92","value":"0.67"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.57","value":"0.19"},{"groupId":"OG001","spread":"0.78","value":"0.54"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.49","value":"0.19"},{"groupId":"OG001","spread":"0.83","value":"0.46"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.86","value":"0.46"},{"groupId":"OG001","spread":"0.92","value":"0.67"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 7"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.94","value":"0.62"},{"groupId":"OG001","spread":"0.78","value":"0.42"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.70","value":"0.42"},{"groupId":"OG001","spread":"0.78","value":"0.42"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 9"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.49","value":"0.19"},{"groupId":"OG001","spread":"0.77","value":"0.38"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 10"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.54","value":"0.15"},{"groupId":"OG001","spread":"0.77","value":"0.38"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 11"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.28","value":"0.08"},{"groupId":"OG001","spread":"0.62","value":"0.29"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"title":"Day 12"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.00","value":"0.00"},{"groupId":"OG001","spread":"0.46","value":"0.13"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"23"}],"units":"Participants"}],"title":"Day 13"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.44","value":"0.12"},{"groupId":"OG001","spread":"0.43","value":"0.09"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"25"},{"groupId":"OG001","value":"22"}],"units":"Participants"}],"title":"Day 14"}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"24"}],"units":"Participants"}],"description":"Grade 0 vomiting is defined as no vomiting. Grade 1 vomiting is defined as intervention not indicated. Grade 2 vomiting is defined as outpatient IV hydration; medical intervention indicated. Grade 3 vomiting is defined as tube feeding, TPN, or hospitalization indicated. Grade 4 vomiting is defined as life-threatening consequences. Grade 5 vomiting is defined as death.","dispersionType":"Standard Deviation","groups":[{"description":"Patients will receive six doses of Uproleselan intravenously. The doses will begin the evening of Day -3 and continue every 12 hours through the morning of Day 0, prior to hematopoietic stem cell transplant (auto-HCT). On the evening of Day -2, patients also receive one dose of standard of care Melphalan intravenously.","id":"OG000","title":"Uproleselan + Standard of Care Melphalan"},{"description":"Patients will receive six doses of placebo intravenously. The doses will begin the evening of Day -3 and continue every 12 hours through the morning of Day 0, prior to hematopoietic stem cell transplant (auto-HCT). On the evening of Day -2, patients also receive one dose of standard of care Melphalan intravenously.","id":"OG001","title":"Placebo + Standard of Care Melphalan"}],"paramType":"MEAN","populationDescription":"The number of participants analyzed at each time point may differ from the overall number of participants analyzed because the data was not collected. One patient in the placebo + standard of care melphalan arm was not evaluable for the outcome measure.","reportingStatus":"POSTED","timeFrame":"From day -3 to date of discharge or day 14 (whichever is sooner) (up to be 18 days)","title":"Change in Vomiting as Assessed Per CTCAE v5.0","type":"SECONDARY","unitOfMeasure":"CTCAE grade"}