{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"19"}]}],"title":"ANC ≥ 0.5 x 10e9/L at 30 days"},{"categories":[{"measurements":[{"groupId":"OG000","value":"19"}]}],"title":"ANC ≥ 0.5 x 10e9/L at 100 days"}],"denoms":[{"counts":[{"groupId":"OG000","value":"19"}],"units":"Participants"}],"description":"Maintenance of successful engraftment after initial engraftment is an important assessment of the value of the mobilization and hematopoietic stem cells (HSC) infusion procedure. For participants with successful neutrophil engraftment \\[absolute neutrophil count (ANC) ≥ 0.5 x 10e9/L\\], the outcome is reported as the number of participants that had maintained successful graft status \\[absolute neutrophil count (ANC) ≥ 0.5 x 10e9/L\\] at 30 days and 100 days after the infusion. The outcome is a number without dispersion.","groups":[{"description":"Patients after screening will undergo baseline evaluation during the premobilization phase up to 30 days before mobilization. Patients will undergo sequential administration of plerixafor 0.24 mg/kg subcutaneously followed 2 hours later by MGTA-145 at 0.03 mg/kg intravenously (3 to10 minute infusion). This will be followed by apheresis. A second day of mobilization and apheresis will be pursued in patients who have not collected 6.0 x 106 CD34+ cells/kg in one session.\n\nMGTA-145: A chemokine receptor type 2 (CXCR2) agonist protein, administered via intravenous (IV) infusion over 3 to 10 minutes.\n\nPlerixafor: An azamacrocycle CXCR4 chemokine receptor antagonist, administered at 0.24 mg/kg subcutaneously, reduced to 0.16 mg/kg in patients with renal dysfunction (per package insert).","id":"OG000","title":"MGTA-145 and Plerixafor HSC Mobilization"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"This outcome is limited to participants that proceeded to the hematopoietic stem cell (HSC) infusion procedure, and with successful neutrophil engraftment.","reportingStatus":"POSTED","timeFrame":"100 days","title":"Maintenance of Neutrophil Engraftment [Absolute Neutrophil Count (ANC) ≥ 0.5 x 10e9/L]","type":"SECONDARY","unitOfMeasure":"Participants"}