{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.6","value":"-5.0"},{"groupId":"OG001","spread":"6.6","value":"0.1"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"21"},{"groupId":"OG001","value":"27"}],"units":"Participants"}],"description":"A study-specific 128-Hz tuning fork will be used to assess vibration sensation on the great toe at baseline and 3 months. The time in seconds to loss of vibration sensation was measured. Vibration sensation is lost sooner in CIPN, which means that shorter duration of vibration scores are associated with increased CIPN. The difference from baseline to 3 months in number of seconds to loss of vibration sensation was calculated for each patient. The differences were averaged across patients in each arm. The mean differences were compared between arms.","dispersionType":"Standard Deviation","groups":[{"description":"Patients undergo acupuncture during chemotherapy infusion on day 1 and fluorouracil pump disconnect on day 3 of each biweekly chemotherapy infusion over 12 weeks. Patients also undergo self-administered acupressure over 11 minutes daily for 12 weeks and undergo standard of care oral cryotherapy.\n\nAcupuncture Therapy: Undergo acupuncture\n\nAcupressure Therapy: Undergo acupressure\n\nOral Cryotherapy: Undergo oral cryotherapy\n\nQuestionnaire Administration: Ancillary studies\n\nQuality-of-Life Assessment: Ancillary studies","id":"OG000","title":"Arm I (Acupuncture, Acupressure, Cryotherapy)"},{"description":"Patients undergo standard of care oral cryotherapy.\n\nOral Cryotherapy: Undergo oral cryotherapy\n\nQuestionnaire Administration: Ancillary studies\n\nQuality-of-Life Assessment: Ancillary studies","id":"OG001","title":"Arm II (Cryotherapy)"}],"paramType":"MEAN","populationDescription":"Due to missing acupuncture appointments the overall number of participants analyzed differs from patients that completed the study.","reportingStatus":"POSTED","timeFrame":"3 months","title":"Severity of CIPN: Tuning Fork Vibration Sensation Testing","type":"SECONDARY","unitOfMeasure":"seconds"}