{"classes":[{"categories":[{"measurements":[{"groupId":"OG006","value":"800"},{"groupId":"OG007","value":"1400"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"},{"groupId":"OG005","value":"0"},{"groupId":"OG006","value":"26"},{"groupId":"OG007","value":"5"},{"groupId":"OG008","value":"0"}],"units":"Participants"}],"description":"To determine the MTD of NM21-1480 based on Part A. Note, No MTD was identified across all dose levels tested and a technical MTD was defined by the SMC as 800 mg following Part A, which was updated to 1400 mg by the SMC after completion of Part A-2.","groups":[{"description":"Part A Dose Level 1 NM21-1480-Q2W 0.15mg","id":"OG000","title":"Part A Dose Level 1 NM21-1480-Q2W 0.15mg"},{"description":"Part A Dose Level 2 NM21-1480-Q2W 1.5mg","id":"OG001","title":"Part A Dose Level 2 NM21-1480-Q2W 1.5mg"},{"description":"Part A Dose Level 3 NM21-1480-Q2W 8mg","id":"OG002","title":"Part A Dose Level 3 NM21-1480-Q2W 8mg"},{"description":"Part A Dose Level 4 NM21-1480-Q2W 24mg","id":"OG003","title":"Part A Dose Level 4 NM21-1480-Q2W 24mg"},{"description":"Part A Dose Level 5 NM21-1480-Q2W 80mg","id":"OG004","title":"Part A Dose Level 5 NM21-1480-Q2W 80mg"},{"description":"Part A Dose Level 6 NM21-1480-Q2W 240mg","id":"OG005","title":"Part A Dose Level 6 NM21-1480-Q2W 240mg"},{"description":"Part A Dose Level 7 NM21-1480-Q2W 800mg","id":"OG006","title":"Part A Dose Level 7 NM21-1480-Q2W 800mg"},{"description":"Part A2 NM21-1480-Q2W 1400mg","id":"OG007","title":"Part A2 NM21-1480-Q2W 1400mg"},{"description":"Part B NM21-1480-Q2W 800mg","id":"OG008","title":"Part B NM21-1480-Q2W 800mg"}],"paramType":"NUMBER","populationDescription":"MTD of NM21-1480 based on Part A and part A2. No MTD was identified across all dose levels tested and a technical MTD was defined by the SMC as 800 mg following Part A, which was updated to 1400 mg by the SMC after completion of Part A-2.","reportingStatus":"POSTED","timeFrame":"Cycle 1 (28 days).","title":"Maximum Tolerated Dose (MTD) of NM21-1480","type":"PRIMARY","unitOfMeasure":"mg"}