{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.194","upperLimit":"0.440","value":"0.292"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"47"}],"units":"Participants"}],"description":"Progression free survival is defined as time from treatment start date to date of progression or death from any cause, whichever occurs first. Disease progression was evaluated using the Response Evaluation Criteria in Solid Tumors version 1.1, the Cheson (2014) criteria for lymphoma patients, and the Response Assessment in Neuro-Oncology criteria for glioblastoma patients. 6 month PFS rate was estimated using the Kaplan-Meier method, which can provide a point estimate for any specific time point.","dispersionType":"90% Confidence Interval","groups":[{"description":"Patients receive binimetinib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.\n\nBinimetinib: Given PO","id":"OG000","title":"Treatment (Binimetinib)"}],"paramType":"NUMBER","populationDescription":"Patients who were eligible and received protocol treatment","reportingStatus":"POSTED","timeFrame":"Tumor assessments occurred at baseline, then every 2 cycles for the first 26 cycles, and every 3 cycles thereafter until disease progression, up to 3 years post registration, from which 6-month PFS is determined","title":"6-Month Progression-free Survival (PFS) Rate","type":"SECONDARY","unitOfMeasure":"percentage of participants"}