{"groups":[{"description":"This group of the study will receive 100mg of Bevonescein (ALM-488).\n\nBevonescein (ALM-488): ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue. 100mg of ALM-488 will be intravenously infused.","id":"FG000","title":"Dose Defining Cohort 100mg"},{"description":"This group of the study will receive 200mg of ALM-488.\n\nALM-488: ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue. 200mg of ALM-488 will be intravenously infused.","id":"FG001","title":"Dose Defining Cohort 200mg"},{"description":"This group of the study will receive 400mg of Bevonescein (ALM-488).\n\nBevonescein (ALM-488): ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue. 400mg of ALM-488 will be intravenously infused.","id":"FG002","title":"Dose Defining Cohort 400mg"},{"description":"This group of the study will receive 500mg of Bevonescein (ALM-488).\n\nBevonescein (ALM-488): ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue. 500mg of ALM-488 will be intravenously infused.","id":"FG003","title":"Dose Defining Cohort 500mg"},{"description":"This group of the study will receive 600mg of Bevonescein (ALM-488).\n\nBevonescein (ALM-488): ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue. 600mg of ALM-488 will be intravenously infused.","id":"FG004","title":"Dose Defining Cohort 600mg"},{"description":"This arm of the study will include patients infused wtih Bevonescein (ALM-488) at 500mg 3-5 hours prior to skin incision.\n\nBevonescein (ALM-488): ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue.","id":"FG005","title":"Dose Timing Cohort 3-5 Hours"},{"description":"This arm of the study will include patients infused wtih Bevonescein (ALM-488) at 500mg 1-3 hours prior to skin incision.\n\nBevonescein (ALM-488): ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue.","id":"FG006","title":"Dose Timing Cohort 1-3 Hours"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"},{"groupId":"FG003","numSubjects":"0"},{"groupId":"FG004","numSubjects":"1"},{"groupId":"FG005","numSubjects":"0"},{"groupId":"FG006","numSubjects":"0"}],"type":"COVID-19 related hospitalization"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"},{"groupId":"FG003","numSubjects":"0"},{"groupId":"FG004","numSubjects":"0"},{"groupId":"FG005","numSubjects":"1"},{"groupId":"FG006","numSubjects":"0"}],"type":"Physician Decision"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"3"},{"groupId":"FG002","numSubjects":"3"},{"groupId":"FG003","numSubjects":"3"},{"groupId":"FG004","numSubjects":"3"},{"groupId":"FG005","numSubjects":"6"},{"groupId":"FG006","numSubjects":"6"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"3"},{"groupId":"FG002","numSubjects":"3"},{"groupId":"FG003","numSubjects":"3"},{"groupId":"FG004","numSubjects":"2"},{"groupId":"FG005","numSubjects":"5"},{"groupId":"FG006","numSubjects":"6"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"},{"groupId":"FG003","numSubjects":"0"},{"groupId":"FG004","numSubjects":"1"},{"groupId":"FG005","numSubjects":"1"},{"groupId":"FG006","numSubjects":"0"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}]}