{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.00","value":"0.50"},{"groupId":"OG001","spread":"0.00","value":"0.50"},{"groupId":"OG002","spread":"0.00","value":"0.50"},{"groupId":"OG003","spread":"0.14","value":"0.42"},{"groupId":"OG004","spread":"0.14","value":"0.42"},{"groupId":"OG005","spread":"0.13","value":"0.42"},{"groupId":"OG006","spread":"0.14","value":"0.40"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"6"},{"groupId":"OG006","value":"6"}],"units":"Participants"}],"description":"Time of peak ALM-488 concentration in plasma following intravenous ALM-488 infusion (hours).","dispersionType":"Standard Deviation","groups":[{"description":"This arm of the study will include Dose Defining 100mg cohort.\n\nALM-488: ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue.","id":"OG000","title":"Dose Defining 100mg"},{"description":"This arm of the study will include Dose Defining 200mg cohort.\n\nALM-488: ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue.","id":"OG001","title":"Dose Defining 200mg"},{"description":"This arm of the study will include Dose Defining 400mg cohort.\n\nALM-488: ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue.","id":"OG002","title":"Dose Defining 400mg"},{"description":"This arm of the study will include Dose Defining 500mg cohort.\n\nALM-488: ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue.","id":"OG003","title":"Dose Defining 500mg"},{"description":"This arm of the study will include Dose Defining 600mg cohort.\n\nALM-488: ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue.","id":"OG004","title":"Dose Defining 600mg"},{"description":"This arm of the study will include Dose timing of ALM-488 administration 1-3hrs before surgery cohort.\n\nALM-488: ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue.","id":"OG005","title":"Dose Timing 1-3hrs"},{"description":"This arm of the study will include Dose timing of ALM-488 administration 3-5hrs before surgery cohort.\n\nALM-488: ALM-488 Sterile Solution is an intravenously administered, synthetic, peptide dye conjugate indicated for the real-time intraoperative fluorescence detection and localization of nerve tissue.","id":"OG006","title":"Dose Timing 3-5 Hours."}],"paramType":"MEAN","populationDescription":"Patients were accrued into the Dose Defining Cohorts (Dose Escalation/De-Escalation) and the Dose Timing Cohorts using inclusion and exclusion criteria as specified in the protocol.","reportingStatus":"POSTED","timeFrame":"28 (+5) days","title":"Time of Peak ALM-488 Concentration in Plasma (Cmax)","type":"OTHER_PRE_SPECIFIED","unitOfMeasure":"hours"}