{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"0"}],"units":"Participants"}],"description":"Dose-limiting toxicities were defined as AEs occurring during this period that meet any of the following criteria, were not related to the primary disease, complication(s), or concomitant medication(s), and has a reasonable relationship with ASTX660. The Common Terminology Criteria for Adverse Events Version 4.03 (CTCAE v4.03) was used to determine severity.\n\n1. Grade 4 thrombocytopenia, Grade 3 or higher clinically significant bleeding, or anemia requiring a new erythrocyte transfusion\n2. Febrile neutropenia that does not resolve within 3 days or Grade 4 neutropenia that lasts for more than 7 days under appropriate treatment\n3. Liver-associated abnormalities\n4. Excepting the above AEs, any other Grade 3 or higher nonhematologic or Grade 4 hematologic toxicity except Grade 3 nausea, vomiting, or diarrhea lasting less than 48 hours","groups":[{"description":"ASTX660 120mg was orally administered once a day for 7 consecutive days every other week of each 28-day cycle (ie, \\[7 days on/ 7 days off\\] ×2; daily dosing on Days 1-7 and 15-21).","id":"OG000","title":"Cohort 1"},{"description":"ASTX660 150mg was orally administered once a day for 7 consecutive days every other week of each 28-day cycle (ie, \\[7 days on/ 7 days off\\] ×2; daily dosing on Days 1-7 and 15-21).","id":"OG001","title":"Cohort 2"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"The DLT analysis population include all subjects who received at least 1 dose of IMP and have available data necessary for DLT assessment during the DLT assessment period.","reportingStatus":"POSTED","timeFrame":"28 days (Day1 to Day29)","title":"Safety (Phase 1 Dose-escalation Part) - Number of Subjects With Dose-limiting Toxicities (DLTs), AEs, Abnormal Clinical Laboratory Values or Physical Exam Results","type":"PRIMARY","unitOfMeasure":"Participants"}