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Pre-Dose (Plasma Concentrations of Fruquintinib)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.1","value":"19.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"}],"units":"Participants"}],"title":"Cycle 9 Day 1 - Pre-Dose (Plasma Concentrations of M11)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.4","value":"13.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"}],"units":"Participants"}],"title":"Cycle 11 Day 1 - Pre-Dose (Plasma Concentrations of Fruquintinib)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.3","value":"17.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"}],"units":"Participants"}],"title":"Cycle 11 Day 1 - Pre-Dose (Plasma Concentrations of M11)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"15.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Cycle 13 Day 1 - Pre-Dose (Plasma Concentrations of Fruquintinib)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"23.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Cycle 13 Day 1 - Pre-Dose (Plasma Concentrations of M11)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Cycle 15 Day 1 - Pre-Dose (Plasma Concentrations of Fruquintinib)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"19.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Cycle 15 Day 1 - Pre-Dose (Plasma Concentrations of M11)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Cycle 17 Day 1 - Pre-Dose (Plasma Concentrations of Fruquintinib)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"15.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Cycle 17 Day 1 - Pre-Dose (Plasma Concentrations of M11)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"312"}],"units":"Participants"}],"description":"Plasma samples were collected from the participants at the defined time points. Plasma concentrations were measured using a validated, specific, and sensitive liquid chromatography tandem mass spectrometry method. M11 is the active metabolite for the study drug.","dispersionType":"Standard Deviation","groups":[{"description":"Participants received 5 mg of fruquintinib oral capsule in combination with BSC once daily for 3 weeks of continuous dosing followed by a 1-week break during a treatment cycle (Each cycle length was 28 days).","id":"OG000","title":"Fruquintinib + BSC Group"}],"paramType":"MEAN","populationDescription":"PK population was used for tabulation of fruquintinib and M11 concentrations from PK plasma samples collected from the Fruquintinib + BSC Group. PK samples for the Placebo + BSC Group were not analyzed. Here, \"Overall Number of Participants Analyzed\" signifies those participants in the Fruquintinib + BSC Group who were evaluable for this outcome measure and \"number analyzed\" signifies those participants who were evaluable at the specified timepoints.","reportingStatus":"POSTED","timeFrame":"Cycle 1 (Day 1 and 21): Pre-dose, 1, 2, 3 and 4 hours; Cycle 2 (Day 21): Predose and 2 hours, Cycle 3 (Day 1): Pre-dose, Cycle 3 (Day 21): Pre-dose and 2 hours, Cycle 5, 7, 9, 11, 13, 15 and 17 (Day 1): Pre-dose (Each cycle = 28 days)","title":"Observed Plasma Concentrations of Fruquintinib and Metabolite M11","type":"SECONDARY","unitOfMeasure":"nanogram/milliliter (ng/mL)"}