{"analyses":[{"ciLowerLimit":"0.549","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.800","estimateComment":"The HR between 2 treatment groups (fruquintinib vs placebo), together with its 95 percent (%) confidence interval (CI), was calculated from a stratified Cox proportional hazards model accounting for the randomization schedule stratification factors.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"< .001","pValueComment":"Raw unadjusted p-value was obtained by using a stratified log-rank test accounting for the randomization schedule stratification factors.","paramType":"Stratified Hazard Ratio","paramValue":"0.662","statisticalMethod":"stratified log-rank test"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"6.7","upperLimit":"8.2","value":"7.4"},{"groupId":"OG001","lowerLimit":"4.0","upperLimit":"5.8","value":"4.8"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"461"},{"groupId":"OG001","value":"230"}],"units":"Participants"}],"description":"OS was defined as the time (months) from date of randomization to death from any cause. OS was calculated as (date of death or last known alive - date of randomization + 1)/30.4375. Participants without report of death at the time of analysis will be censored at the date last known alive.","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants received 5 mg of fruquintinib oral capsule in combination with BSC once daily for 3 weeks of continuous dosing followed by a 1-week break during a treatment cycle (Each cycle length was 28 days).","id":"OG000","title":"Fruquintinib + BSC Group"},{"description":"Participants received placebo matched to fruquintinib oral capsule in combination with BSC once daily for 3 weeks of continuous dosing followed by a 1-week break during a treatment cycle (Each cycle length was 28 days).","id":"OG001","title":"Placebo + BSC Group"}],"paramType":"MEDIAN","populationDescription":"ITT population included all randomized participants.","reportingStatus":"POSTED","timeFrame":"From date of randomization to death from any cause (up to 22 months)","title":"Overall Survival (OS)","type":"PRIMARY","unitOfMeasure":"months"}