{"description":"MedDRA 24.1 coding dictionary was applied for all AE tables. The same event may appear as both an AE and an SAE. However, what is presented are distinct events. An event may be categorized as serious in one participant and as non-serious in another participant, or one participant may have experienced both a serious and non-serious event during the study.","eventGroups":[{"deathsNumAffected":1,"deathsNumAtRisk":10,"description":"During the 12-week treatment period, participants receive a total of 5 SC doses of PF-06946860 Q3W.","id":"EG000","otherNumAffected":10,"otherNumAtRisk":10,"seriousNumAffected":4,"seriousNumAtRisk":10,"title":"PF-06946860 Q3W"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":10}],"term":"Anaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Monocytosis"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Thrombocytopenia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Thrombocytosis"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Sinus tachycardia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Endocrine disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypothyroidism"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Eye disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Conjunctival hyperaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Eye disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Lacrimation increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Abdominal discomfort"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Abdominal distension"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Abdominal pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Abdominal pain upper"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":10}],"term":"Diarrhoea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Epigastric discomfort"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":10}],"term":"Nausea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Oral pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Vomiting"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Asthenia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":10}],"term":"Fatigue"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"COVID-19"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Conjunctivitis"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Upper respiratory tract infection"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Urinary tract infection"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Contusion"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Fall"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Oral contusion"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Skin laceration"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Alanine aminotransferase increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Aspartate aminotransferase increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Blood alkaline phosphatase increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Blood bilirubin increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Electrocardiogram Q wave abnormal"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Neutrophil count decreased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Platelet count decreased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Decreased appetite"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Dehydration"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hyperglycaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypoalbuminaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypocalcaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Hypokalaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypomagnesaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Back pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Muscular weakness"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Myalgia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Ataxia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Dizziness"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Dysgeusia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Head discomfort"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypoaesthesia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Paraesthesia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Anxiety"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Confusional state"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Depression"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Insomnia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Renal and urinary disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Dysuria"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Renal and urinary disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Haematuria"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Renal and urinary disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Proteinuria"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Cough"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Epistaxis"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypoxia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Upper-airway cough syndrome"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Rash macular"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Hypertension"}],"seriousEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Anaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Hepatobiliary disorders","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Cholecystitis acute"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Sepsis"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Transaminases increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Neoplasms benign, malignant and unspecified (incl cysts and polyps)","sourceVocabulary":"MedDRA v24.1","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Malignant neoplasm progression"}],"timeFrame":"From Day 1 up to Week 24"}