{"classes":[{"categories":[{"measurements":[{"comment":"None of the participants achieved ORR. Thus, upper and lower limit of confidence interval values could not be calculated.","groupId":"OG000","lowerLimit":"NA","upperLimit":"NA","value":"0"},{"groupId":"OG001","lowerLimit":"0.0","upperLimit":"22.2","value":"7.7"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"description":"ORR: Percentage of participants with best response of CR or PR per Response Evaluation Criteria in Solid Tumors (RECIST) or Response Assessment in Neuro-Oncology (RANO).\n\nRECIST was used for solid tumors and RANO was used for brain tumors.\n\n* CR is defined as the disappearance of all target lesions (RECIST) and disappearance of all enhancing measurable and non-measurable disease, no new lesions; stable or improved non-enhancing lesions; and patient must be off corticosteroids and stable or improved clinically (RANO).\n* PR is defined as a 30% decrease in the sum of diameters of target lesions (RECIST) and \\>50% decrease in the sum of products of perpendicular diameters of all measurable enhancing lesions, no progression of non-measurable disease, no new lesions, stable/improved non-enhancing lesions on same or lower dose of corticosteroids and patient is stable or improved clinically (RANO).","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants received:\n\n* Abemaciclib: 70 mg/m², administered orally twice daily (BID).\n* Irinotecan: 50 mg/m²/day, administered IV on Days 1-5 of each cycle.\n* Temozolomide: 100 mg/m²/day, administered orally on Days 1-5 of each cycle.\n\nTreatment continued until progressive disease, a discontinuation criterion, or unacceptable toxicity. Each cycle lasted 21 days.","id":"OG000","title":"Part A Cohort A1"},{"description":"Participants received:\n\n* Abemaciclib: 55 mg/m², administered orally BID.\n* Irinotecan: 50 mg/m²/day, administered IV on Days 1-5 of each cycle.\n* Temozolomide: 100 mg/m²/day, administered orally on Days 1-5 of each cycle.\n\nTreatment continued until progressive disease, a discontinuation criterion, or unacceptable toxicity. Each cycle lasted 21 days.","id":"OG001","title":"Part A Cohort A-1"}],"paramType":"NUMBER","populationDescription":"All participants in Part A who received at least one dose of the study drug and had evaluable data for this outcome. Per pre-specified statistical analysis plan, analysis was performed as per the study treatments received.","reportingStatus":"POSTED","timeFrame":"Date of first dose to disease progression or death (Up to 25 Months)","title":"Percentage of Participants With Overall Response Rate (ORR): Part A","type":"SECONDARY","unitOfMeasure":"Percentage of participants"}