{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"19","value":"15800"},{"groupId":"OG001","spread":"13","value":"24300"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"11"}],"units":"Participants"}],"title":"Cycle 1, Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21","value":"15700"},{"groupId":"OG001","spread":"43","value":"21100"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"10"}],"units":"Participants"}],"title":"Cycle 2, Day 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"11"}],"units":"Participants"}],"description":"PK: AUC0-tlast was reported.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"All part B participants who received 100 mg/m²/day temozolomide were included under this arm.","id":"OG000","title":"Part B: 100 mg/m²/Day Temozolomide"},{"description":"All part B participants who received 150 mg/m²/day temozolomide were included under this arm.","id":"OG001","title":"Part B: 150 mg/m²/Day Temozolomide"}],"paramType":"GEOMETRIC_LEAST_SQUARES_MEAN","populationDescription":"All Part B participants in who received at least one dose of temozolomide and had evaluable PK data. Per planned analysis, PK analysis was performed as per the dose of drug received.","reportingStatus":"POSTED","timeFrame":"1, 2.5, 4, and 6 hours post Day 1 dose of Cycle 1 and Cycle 2 (21 Day Cycle)","title":"PK: AUC0-tlast of Temozolomide in Part B","type":"PRIMARY","unitOfMeasure":"ng*h/mL"}