{"classes":[{"categories":[{"measurements":[{"comment":"Upper limit can not be estimated due to insufficient number of patients with events.","groupId":"OG000","lowerLimit":"11.4","upperLimit":"NA","value":"19.2"},{"groupId":"OG001","lowerLimit":"4.8","upperLimit":"10.9","value":"7.7"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"42"},{"groupId":"OG001","value":"30"}],"units":"Participants"}],"description":"Will assess the time from the first dose of the study treatment until death from any cause, up to a maximum follow-up of two years.","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients received oral cabozantinib 40 mg (as a starting dose) once per day and temozolomide 150 mg/m² on days 1-5 of a 28-day cycle for cycle one. Starting from cycle two, temozolomide was escalated to 200 mg/m² on days 1-5 of each cycle, if the absolute neutrophil count was more than 1·5 × 10⁹/L and platelet count was more than 100·0 × 10⁹/L. Treatment was continued until disease progression or unacceptable drug-related toxicity.","id":"OG000","title":"Cohort 1 - Patients With Unresectable or Metastatic Uterine and Non-uterine Leiomyosarcoma"},{"description":"Patients with gastrointestinal stromal tumour, dermatofibrosarcoma, alveolar soft part sarcoma, kaposi sarcoma, mixed mesodermal tumour or carcinosarcoma, alveolar and embryonal rhabdomyosarcoma, and low grade sarcomas were not included.\n\nPatients received oral cabozantinib 40 mg (as a starting dose) once per day and temozolomide 150 mg/m² on days 1-5 of a 28-day cycle for cycle one. Starting from cycle two, temozolomide was escalated to 200 mg/m² on days 1-5 of each cycle, if the absolute neutrophil count was more than 1·5 × 10⁹/L and platelet count was more than 100·0 × 10⁹/L. Treatment was continued until disease progression or unacceptable drug-related toxicity.","id":"OG001","title":"Cohort 2 - Patients With Other Soft Tissue Sarcomas"}],"paramType":"MEDIAN","reportingStatus":"POSTED","timeFrame":"Up to 2 years","title":"Overall Survival (OS)","type":"SECONDARY","unitOfMeasure":"months"}