{"classes":[{"categories":[{"measurements":[{"comment":"Median and upper limit of 95% Confidence Interval unavailable due to high censoring.","groupId":"OG000","lowerLimit":"14.75","upperLimit":"NA","value":"NA"},{"comment":"Median and upper limit of 95% Confidence Interval unavailable due to high censoring.","groupId":"OG001","lowerLimit":"8.74","upperLimit":"NA","value":"NA"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"}],"units":"Participants"}],"description":"Intracranial DOR per RECIST 1.1 by BICR (with Pembrolizumab)","dispersionType":"95% Confidence Interval","groups":[{"description":"160 mg Selpercatinib administered orally BID continuously in 21-day cycles.","id":"OG000","title":"Selpercatinib (TRT A)"},{"description":"Pemetrexed 500 mg/m2, IV on Day 1 Q3W plus investigator's choice of carboplatin AUC 5 (maximum dose 750 mg) IV or cisplatin 75mg/m2, IV on Day 1 Q3W for 4 cycles, plus investigator's choice with 200 mg pembrolizumab IV on Day 1 Q3W up to 35 cycles.","id":"OG001","title":"Pemetrexed and Platinum With Pembrolizumab (TRT B)"}],"paramType":"MEDIAN","populationDescription":"CNS Pembrolizumab: Participants included in the ITT population who were stratified with the intent to receive pembrolizumab in the event of the control-arm assignment who had baseline CNS assessment and who had CNS metastasis at baseline. Participants censored: TRT A: 13; TRT B: 9.","reportingStatus":"POSTED","timeFrame":"Date of Intracranial CR or PR to Date of CNS Progression or Death Due to Any Cause Up to 31 Months","title":"Median Intracranial DOR Per RECIST 1.1 by BICR (With Pembrolizumab)","type":"SECONDARY","unitOfMeasure":"Months"}