{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"}],"title":"Max grade 3"},{"measurements":[{"groupId":"OG000","value":"2"}],"title":"Max grade 2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"0"}],"units":"Participants"}],"description":"Number of patients by worst recorded grade of acute toxicity, assessed using CTCAE v5.0","groups":[{"description":"Patients will receive an initial dose of pembrolizumab in week 1 dosed at 200 mg. They will then receive SBRT dosed at 30 Gy in 3 fractions (#) alternate days in week 3. Treatment with pembrolizumab will be continued dosed at 200 mg given every 3 weeks.\n\nPembrolizumab: Pembrolizumab will be continued dosed at 200 mg given every 3 weeks\n\nDrug: Pembrolizumab Pembrolizumab in week 1 dosed at 200 mg (prior to SBRT) and then treatment with pembrolizumab will be continued dosed at 200 mg given every 3 weeks.\n\nStereotactic Body Radiotherapy (SBRT): Stereotactic Body Radiotherapy (SBRT) 30 Gy 3 fractions (#)","id":"OG000","title":"Initial Safety Cohort"},{"description":"An additional 12 patients will be recruited for this cohort. Patients will receive an initial dose of pembrolizumab at 200 mg in week 1. This will be followed in by SBRT dosed at 30 Gy in 3 fractions (#) alternate days in week 3. Treatment with pembrolizumab will be continued dosed at 200 mg given every 3 weeks.\n\nPembrolizumab: Pembrolizumab will be continued dosed at 200 mg given every 3 weeks\n\nDrug: Pembrolizumab Pembrolizumab in week 1 dosed at 200 mg (prior to SBRT) and then treatment with pembrolizumab will be continued dosed at 200 mg given every 3 weeks.\n\nStereotactic Body Radiotherapy (SBRT): Stereotactic Body Radiotherapy (SBRT) 30 Gy 3 fractions (#)","id":"OG001","title":"Expansion Cohort"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"All patients who received at least one dose of trial treatment","reportingStatus":"POSTED","timeFrame":"Worst grade as assessed at cycle 1 day 1 of pembrolizumab, at each of three radiotherapy fractions (cycle 1 days 15, 17, 19) and then at day 1 of each 21 day cycle, up to 12 weeks from last dose of SBRT (i.e. cycle 6 day 1)","title":"Worst Acute Toxicity Grade","type":"SECONDARY","unitOfMeasure":"Participants"}