{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"}]}],"title":"Ic. BS RR <20 breaths/min, on TR ch =<5 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"}]}],"title":"Ic.BS RR<20 breaths/min, on TR Ch >5 - = <10 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Ic. BS RR <20 breaths/min, on TR ch >10 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"}]}],"title":"Ic. BS RR >=20 breaths/min, on TR ch =<5 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"IC.BS RR >=20 breaths/min, on TR ch >5 - =<10 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Ic. BS RR >=20 breaths/min, on TR ch >10 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"4"}]}],"title":"Dc. BS RR <20 breaths/min, on TR ch =<5 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS RR <20 breaths/min, on TR Ch >5 - =<10 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS RR <20 breaths/min, on TR ch >10 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS RR >=20 breaths/min, on TR ch =<5 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc.BS RR >=20 breaths/min, on TR ch >5 - =<10 breaths/min"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS RR >=20 breaths/min, on TR ch >10 breaths/min"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"4"}],"units":"Participants"}],"description":"The number of participants with treatment-emergent changes from baseline in Increase (Ic.)/Decrease (Dc.) maximal Respiration Rate (RR) were reported by using criteria: Ic./Dc. BS RR \\<20 breaths per minute (breaths/min), on TR change (ch) =\\<5 breaths/min, \\>5 - =\\<10 breaths/min and \\>10 breaths/min. Ic./Dc. BS RR \\>=20 breaths/min, on TR ch =\\<5 breaths/min, \\>5 - =\\<10 breaths/min and \\>10 breaths/min.","groups":[{"description":"Participants received M3258 at a dose of 10 milligrams (mg) orally, once daily (QD) until disease progression.","id":"OG000","title":"M3258 10 mg QD"},{"description":"Participants received M3258 at a dose of 10 mg orally, twice per week on Day 1 and Day 4 until disease progression.","id":"OG001","title":"M3258 10 mg Twice Per Week"},{"description":"Participants received M3258 at a dose of 20 mg orally, twice per week on Day 1 and Day 4 until disease progression.","id":"OG002","title":"M3258 20 mg Twice Per Week"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Safety analysis set included all participants who were administered any dose of the study medication.","reportingStatus":"POSTED","timeFrame":"Time from first treatment up to 30 days after end of study intervention (assessed up to 24.3 weeks)","title":"Part A: Number of Participants With Treatment-Emergent Changes From Baseline in Vital Signs - Maximal Respiration Rate Increase/Decrease","type":"SECONDARY","unitOfMeasure":"Participants"}