{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"}]}],"title":"Ic. BS SBP <140 mmHg, on TR change =<20 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"}]}],"title":"Ic. BS SBP <140 mmHg, on TR change >20 - =<40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"}]}],"title":"Ic. BS SBP <140 mmHg, on TR change >40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"}]}],"title":"Ic. BS SBP >=140 mmHg, on TR change =<20 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Ic. BS SBP >=140 mmHg, on TR change >20 - =<40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Ic. BS SBP >=140 mmHg, on TR change >40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"3"}]}],"title":"Dc. BS SBP <140 mmHg, on TR change =<20 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS SBP <140 mmHg, on TR change >20 - =<40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS SBP <140 mmHg, on TR change >40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"}]}],"title":"Dc. BS SBP >=140 mmHg, on TR change =<20 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS SBP >=140 mmHg, on TR change >20 - =<40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS SBP >=140 mmHg, on TR change >40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"3"}]}],"title":"Ic. BS DBP <90 mmHg, on TR change =<20 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}]}],"title":"Ic. BS DBP <90 mmHg, on TR change >20 - =<40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}]}],"title":"Ic. BS DBP <90 mmHg, on TR change >40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"}]}],"title":"Ic. BS DBP >=90 mmHg, on TR change =<20 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Ic. BS DBP >=90 mmHg, on TR change >20 - =<40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Ic. BS DBP >=90 mmHg, on TR change >40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"3"}]}],"title":"Dc. BS DBP <90 mmHg, on TR change =<20 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS DBP <90 mmHg, on TR change >20 - =<40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS DBP <90 mmHg, on TR change >40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"}]}],"title":"Dc. BS DBP >=90 mmHg, on TR change =<20 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS DBP >=90 mmHg,on TR change >20 - =<40 mmHg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Dc. BS DBP >=90 mmHg, on TR change >40 mmHg"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"4"}],"units":"Participants"}],"description":"The number of participants with treatment-emergent changes from baseline (BS) in Increase (Ic.)/Decrease (Dc.) Systolic Blood Pressure (SBP) and diastolic blood pressure (DBP) (millimeter of mercury \\[mmHg\\]) were reported by using criteria: Ic./Dc. BS SBP/DBP \\<140/\\<90 mmHg, on maximal treatment (TR) change =\\<20 mmHg, \\>20 - =\\<40 mmHg and \\>40 mmHg; Ic./Dc. BS SBP/DBP \\>=140/\\>=90 mmHg, on maximal TR change =\\<20 mmHg, \\>20 - =\\<40 mmHg and \\>40 mmHg.","groups":[{"description":"Participants received M3258 at a dose of 10 milligrams (mg) orally, once daily (QD) until disease progression.","id":"OG000","title":"M3258 10 mg QD"},{"description":"Participants received M3258 at a dose of 10 mg orally, twice per week on Day 1 and Day 4 until disease progression.","id":"OG001","title":"M3258 10 mg Twice Per Week"},{"description":"Participants received M3258 at a dose of 20 mg orally, twice per week on Day 1 and Day 4 until disease progression.","id":"OG002","title":"M3258 20 mg Twice Per Week"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Safety analysis set included all participants who were administered any dose of the study medication.","reportingStatus":"POSTED","timeFrame":"Time from first treatment up to 30 days after end of study intervention (assessed up to 24.3 weeks)","title":"Part A: Number of Participants With Treatment-Emergent Changes From Baseline in Vital Signs - Maximal Systolic Blood Pressure Increase/Decrease and Maximal Diastolic Blood Pressure Increase/Decrease","type":"SECONDARY","unitOfMeasure":"Participants"}