{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"}]}],"title":"Baseline temp. <37°C, on treatment change <1°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"1"}]}],"title":"Baseline temp.<37°C, on treatment change 1 - <2°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. <37°C, on treatment change 2 - <3°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. <37°C, on treatment change >=3°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"1"}]}],"title":"Baseline temp. 37 - <38°C, on treatment change <1°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 37 - <38°C, on treatment change 1 - <2°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 37 - <38°C, on treatment change 2 - <3°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 37 - <38°C, on treatment change >=3°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 38 - <39°C, on treatment change <1°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 38 - <39°C, on treatment change 1 - <2°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 38 - <39°C, on treatment change 2 - <3°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 38 - <39°C, on treatment change >=3°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 39 - <40°C, on treatment change <1°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 39 - <40°C, on treatment change 1 - <2°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 39 - <40°C, on treatment change 2 - <3°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. 39 - <40°C, on treatment change >=3°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. >=40°C, on treatment change <1°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. >=40°C, on treatment change 1 - <2°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. >=40°C, on treatment change 2 - <3°C"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}]}],"title":"Baseline temp. >=40°C, on treatment change >=3°C"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"4"}],"units":"Participants"}],"description":"The number of participants with treatment-emergent changes from baseline in increased Body Temperature (degree Celsius \\[°C\\]) were reported by using criteria: Baseline temperature (temp.) less than (\\<) 37°C, on treatment change \\<1°C, 1 - \\<2°C, 2 - \\<3°C and greater than or equal to (\\>=)3°C; Baseline temp. 37 - \\<38°C, on treatment change \\<1°C, 1 - \\<2°C, 2 - \\<3°C and \\>=3°C; Baseline temp. 38 - \\<39°C, on treatment change \\<1°C, 1 - \\<2°C, 2 - \\<3°C and \\>=3°C; Baseline temp. 39-\\<40°C, on treatment change \\<1°C, 1 - \\<2°C, 2 - \\<3°C and \\>=3°C; Baseline temp. \\>=40°C, on treatment change \\<1°C, 1 - \\<2°C, 2 - \\<3°C and \\>=3°C.","groups":[{"description":"Participants received M3258 at a dose of 10 milligrams (mg) orally, once daily (QD) until disease progression.","id":"OG000","title":"M3258 10 mg QD"},{"description":"Participants received M3258 at a dose of 10 mg orally, twice per week on Day 1 and Day 4 until disease progression.","id":"OG001","title":"M3258 10 mg Twice Per Week"},{"description":"Participants received M3258 at a dose of 20 mg orally, twice per week on Day 1 and Day 4 until disease progression.","id":"OG002","title":"M3258 20 mg Twice Per Week"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Safety analysis set included all participants who were administered any dose of the study medication.","reportingStatus":"POSTED","timeFrame":"Time from first treatment up to 30 days after end of study intervention (assessed up to 24.3 weeks)","title":"Part A: Number of Participants With Treatment-Emergent Changes From Baseline in Vital Signs - Maximal Body Temperature Increase","type":"SECONDARY","unitOfMeasure":"Participants"}