{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"59.51","value":"45.34"},{"groupId":"OG001","spread":"49.42","value":"42.70"}]}],"title":"Cmin,ss"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"59.80","value":"59.07"},{"groupId":"OG001","spread":"46.26","value":"55.59"}]}],"title":"Cmax,ss"}],"denoms":[{"counts":[{"groupId":"OG000","value":"179"},{"groupId":"OG001","value":"233"}],"units":"Participants"}],"description":"Cmin,ss is the minimum plasma concentration of AZ5104 at steady state. Cmax,ss is the maximum plasma concentration of AZ5104 at steady state.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Osimertinib (AZD9291) 80 mg in combination with pemetrexed (500 mg/m2) plus either cisplatin (75 mg/m2) or carboplatin (AUC5) on Day 1 of 21-day cycles for 4 cycles, followed by Osimertinib (AZD9291) 80 mg QD with Pemetrexed maintenance (500 mg/m2) Q3W","id":"OG000","title":"Randomized: AZD9291 + Chemo"},{"description":"Osimertinib (AZD9291) 80mg QD.","id":"OG001","title":"Randomized: AZD9291"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"Pharmacokinetic Analysis Set, includes all randomized participants that received at least 1 dose of study treatment, have at least 1 measurable PK concentration and no missing doses 7 days prior to the PK sample, without any protocol deviation that affects PK, supported by the relevant date and time of this sample.","reportingStatus":"POSTED","timeFrame":"Up to approximately 33 months after the first patient is randomized.","title":"Mean Cmin,ss and Mean Cmax,ss of AZ5104 (Randomized Component)","type":"SECONDARY","unitOfMeasure":"nmol/L"}