{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.00","upperLimit":"4.13","value":"2.94"},{"groupId":"OG001","lowerLimit":"1.00","upperLimit":"2.03","value":"2.00"},{"groupId":"OG002","lowerLimit":"0.90","upperLimit":"7.50","value":"1.99"},{"groupId":"OG003","lowerLimit":"0.98","upperLimit":"2.00","value":"1.02"},{"groupId":"OG004","lowerLimit":"0.42","upperLimit":"8.00","value":"2.00"},{"groupId":"OG005","lowerLimit":"0.92","upperLimit":"3.97","value":"1.92"},{"groupId":"OG006","lowerLimit":"0.98","upperLimit":"7.55","value":"2.03"},{"groupId":"OG007","lowerLimit":"1.07","upperLimit":"4.10","value":"2.95"}]}],"title":"C1D1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.00","upperLimit":"4.07","value":"2.04"},{"groupId":"OG001","lowerLimit":"0.97","upperLimit":"4.99","value":"2.08"},{"groupId":"OG002","lowerLimit":"1.87","upperLimit":"7.77","value":"3.04"},{"groupId":"OG003","lowerLimit":"1.00","upperLimit":"2.12","value":"1.08"},{"groupId":"OG004","lowerLimit":"0.57","upperLimit":"23.7","value":"2.00"},{"groupId":"OG005","lowerLimit":"0.97","upperLimit":"2.07","value":"1.96"},{"groupId":"OG006","lowerLimit":"1.88","upperLimit":"2.00","value":"1.98"},{"groupId":"OG007","lowerLimit":"4.05","upperLimit":"4.08","value":"4.07"}]}],"title":"C1D15"}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"12"},{"groupId":"OG003","value":"7"},{"groupId":"OG004","value":"65"},{"groupId":"OG005","value":"7"},{"groupId":"OG006","value":"4"},{"groupId":"OG007","value":"4"}],"units":"Participants"}],"description":"Time to achieve peak plasma concentration of RMC-4630 and cobimetinib or RMC-4630 and osimertinib","dispersionType":"Full Range","groups":[{"description":"Participants who received intermittent dose of RMC-4630 80 mg on D1 and D4 of a 28-day cycle and Cobimetinib 20 mg QD 21days on and 7 days off of a 28-day cycle.","id":"OG000","title":"Intermittent RMC-4630 80mg (D1D4) + Cobimetinib 20mg QD (21/7)"},{"description":"Participants who received intermittent dose of RMC-4630 80mg on D1 and D4 of a 28-day cycle and Cobimetinib 40mg QD 21days on and 7 days off of a 28-day cycle.","id":"OG001","title":"Intermittent RMC-4630 80mg (D1D4) + Cobimetinib 40mg QD (21/7)"},{"description":"Participants who received intermittent dose of RMC-4630 140 mg on D1 and D4 of a 28-day cycle and Cobimetinib 20mg QD 21days on and 7 days off of a 28-day cycle.","id":"OG002","title":"Intermittent RMC-4630 140mg (D1D4) + Cobimetinib 20mg QD (21/7)"},{"description":"Participants who received intermittent dose of RMC-4630 140 mg on D1 and D2 of a 28-day cycle and Cobimetinib 20mg QD 21days on and 7 days off of a 28-day cycle.","id":"OG003","title":"Intermittent RMC-4630 140mg (D1D2) + Cobimetinib 20mg QD (21/7)"},{"description":"Participants who received intermittent dose of RMC-4630 140 mg on D1 and D2 of a 28-day cycle and Cobimetinib 40mg D1 and D2 of a 28-day cycle.","id":"OG004","title":"Intermittent RMC-4630 140mg (D1D2) + Cobimetinib 40mg (D1D2)"},{"description":"Participants who received intermittent dose of RMC-4630 140 mg on D1 and D2 of a 28-day cycle and Cobimetinib 60mg D1 and D2 of a 28-day cycle.","id":"OG005","title":"Intermittent RMC-4630 140mg (D1D2) + Cobimetinib 60mg D1D2"},{"description":"Participants who received intermittent dose of RMC-4630 100 mg on D1 and D2 of a 28-day cycle and daily dose of Osimertinib 80 mg from D1 through D28 of a 28-day cycle.","id":"OG006","title":"Intermittent RMC-4630 100mg (D1D2) + Osimertinib 80mg (QD)"},{"description":"Participants who received intermittent dose of RMC-4630 140 mg on D1 and D2 of a 28-day cycle and daily dose of Osimertinib 80 mg from D1 through D28 of a 28-day cycle.","id":"OG007","title":"Intermittent RMC-4630 140mg (D1D2) + Osimertinib 80mg (QD)"}],"paramType":"MEDIAN","reportingStatus":"POSTED","timeFrame":"0, 0.5, 1, 2, 4, 8, 24 hours post-dose on Cycle1 Day 1 and Cycle 1 Day 15","title":"Tmax","type":"SECONDARY","unitOfMeasure":"h"}