{"description":"No patient was enrolled in Part A dose expansion cohort 6 due to conflict with enrollment of Part B.","eventGroups":[{"deathsNumAffected":0,"deathsNumAtRisk":3,"description":"Patients with EGFR or HER2 mutations, previously treated with at least one line of systemic therapy.\n\nPatients received a single dose of 50 mg sunvozertinib, followed by a 7-day washout period. Then, they received 50 mg sunvozertinib once daily continuously.","id":"EG000","otherNumAffected":3,"otherNumAtRisk":3,"seriousNumAffected":0,"seriousNumAtRisk":3,"title":"Part A Dose Escalation Cohort 1: Sunvozertinib 50 mg"},{"deathsNumAffected":1,"deathsNumAtRisk":6,"description":"Patients with EGFR or HER2 mutations, previously treated with at least one line of systemic therapy.\n\nPatients received a single dose of 100 mg sunvozertinib, followed by a 7-day washout period. Then, they received 100 mg sunvozertinib once daily continuously.","id":"EG001","otherNumAffected":6,"otherNumAtRisk":6,"seriousNumAffected":1,"seriousNumAtRisk":6,"title":"Part A Dose Escalation Cohort 2: Sunvozertinib 100 mg"},{"deathsNumAffected":0,"deathsNumAtRisk":3,"description":"Patients with EGFR or HER2 mutations, previously treated with at least one line of systemic therapy.\n\nPatients received a single dose of 200 mg sunvozertinib, followed by a 7-day washout period. Then, they received 200 mg sunvozertinib once daily continuously.","id":"EG002","otherNumAffected":3,"otherNumAtRisk":3,"seriousNumAffected":1,"seriousNumAtRisk":3,"title":"Part A Dose Escalation Cohort 3: Sunvozertinib 200 mg"},{"deathsNumAffected":2,"deathsNumAtRisk":7,"description":"Patients with EGFR or HER2 mutations, previously treated with at least one line of systemic therapy.\n\nPatients received a single dose of 300 mg sunvozertinib, followed by a 7-day washout period. Then, they received 300 mg sunvozertinib once daily continuously.","id":"EG003","otherNumAffected":7,"otherNumAtRisk":7,"seriousNumAffected":4,"seriousNumAtRisk":7,"title":"Part A Dose Escalation Cohort 4: Sunvozertinib 300 mg"},{"deathsNumAffected":0,"deathsNumAtRisk":6,"description":"Patients with EGFR or HER2 mutations, previously treated with at least one line of systemic therapy.\n\nPatients received a single dose of 400 mg sunvozertinib, followed by a 7-day washout period. Then, they received 400 mg sunvozertinib once daily continuously.","id":"EG004","otherNumAffected":6,"otherNumAtRisk":6,"seriousNumAffected":2,"seriousNumAtRisk":6,"title":"Part A Dose Escalation Cohort 5: Sunvozertinib 400 mg"},{"deathsNumAffected":1,"deathsNumAtRisk":10,"description":"Patients with EGFR or HER2 exon20ins, previously treated with at least one line of systemic therapy.\n\nPatients received sunvozertinib 200 mg once daily dosing in the fasted state continuously.","id":"EG005","otherNumAffected":10,"otherNumAtRisk":10,"seriousNumAffected":4,"seriousNumAtRisk":10,"title":"Part A Dose Expansion Cohort 1: Sunvozertinib 200 mg, Dosing in the Fasted State"},{"deathsNumAffected":0,"deathsNumAtRisk":14,"description":"Patients with EGFR or HER2 exon20ins, previously treated with at least one line of systemic therapy.\n\nPatients received sunvozertinib 300 mg once daily dosing in the fasted state continuously.","id":"EG006","otherNumAffected":14,"otherNumAtRisk":14,"seriousNumAffected":5,"seriousNumAtRisk":14,"title":"Part A Dose Expansion Cohort 2: Sunvozertinib 300 mg, Dosing in the Fasted State"},{"deathsNumAffected":2,"deathsNumAtRisk":14,"description":"Patients with EGFR exon20ins, previously treated with at least one line of systemic therapy.\n\nPatients received sunvozertinib 200 mg once daily dosing with a low-fat meal continuously.","id":"EG007","otherNumAffected":14,"otherNumAtRisk":14,"seriousNumAffected":9,"seriousNumAtRisk":14,"title":"Part A Dose Expansion Cohort 3: Sunvozertinib 200 mg; Dosing With a Low-fat Meal"},{"deathsNumAffected":1,"deathsNumAtRisk":7,"description":"Patients with EGFR exon20ins, previously treated with at least one line of systemic therapy.\n\nPatients received sunvozertinib 300 mg once daily dosing with a low-fat meal continuously.","id":"EG008","otherNumAffected":7,"otherNumAtRisk":7,"seriousNumAffected":2,"seriousNumAtRisk":7,"title":"Part A Dose Expansion Cohort 4: Sunvozertinib 300 mg; Dosing With a Low-fat Meal"},{"deathsNumAffected":4,"deathsNumAtRisk":31,"description":"Patients with EGFR exon20ins, treatment naïve. Patients received sunvozertinib 300 mg once daily dosing with a low-fat meal continuously.","id":"EG009","otherNumAffected":31,"otherNumAtRisk":31,"seriousNumAffected":14,"seriousNumAtRisk":31,"title":"Part A Dose Expansion Cohort 5: Treatment naïve, Sunvozertinib 300 mg, Dosing With a Low-fat Meal"},{"deathsNumAffected":0,"deathsNumAtRisk":0,"description":"Patients with EGFR exon20ins, were refractory to, relapsed from, or intolerant to previous amivantamab treatment.\n\nNo patient was enrolled into this cohort.","id":"EG010","otherNumAffected":0,"otherNumAtRisk":0,"seriousNumAffected":0,"seriousNumAtRisk":0,"title":"Part A Dose Expansion Cohort 6: Previously Treated With Amivantamab; Sunvozertinib 300 mg"},{"deathsNumAffected":0,"deathsNumAtRisk":5,"description":"Patients with EGFR exon20ins, previously treated with at least one line of systemic therapy.\n\nPatients were randomized at a 1:1 ratio to receive a single dose of sunvozertinib 300 mg under the High-Fat Meal condition, followed by a 7-day washout and crossed to receive a single dose of sunvozertinib 300 mg under the Fasted condition, followed by a 7-day washout. Then patients received sunvozertinib 300 mg once daily continuously.","id":"EG011","otherNumAffected":5,"otherNumAtRisk":5,"seriousNumAffected":0,"seriousNumAtRisk":5,"title":"Part A Food Effect Cohort 1: Sunvozertinib 300 mg; High-Fat Meal Condition First, Then Fasted"},{"deathsNumAffected":0,"deathsNumAtRisk":7,"description":"Patients with EGFR exon20ins, previously treated with at least one line of systemic therapy.\n\nPatients were randomized at a 1:1 ratio to receive a single dose of sunvozertinib 300 mg under the Fasted condition, followed by a 7-day washout and crossed to receive a single dose of sunvozertinib 300 mg under the High-Fat Meal condition, followed by a 7-day washout. 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