{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-0.74","upperLimit":"8.76","value":"4.01"},{"groupId":"OG001","lowerLimit":"1.75","upperLimit":"9.53","value":"5.64"},{"groupId":"OG002","lowerLimit":"0.70","upperLimit":"7.17","value":"3.94"}]}],"title":"Total Score"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-7.16","upperLimit":"7.13","value":"-0.02"},{"groupId":"OG001","lowerLimit":"-4.02","upperLimit":"7.45","value":"1.71"},{"groupId":"OG002","lowerLimit":"0.52","upperLimit":"8.82","value":"4.67"}]}],"title":"School/Work Functioning"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-4.31","upperLimit":"8.01","value":"1.85"},{"groupId":"OG001","lowerLimit":"2.91","upperLimit":"12.37","value":"7.64"},{"groupId":"OG002","lowerLimit":"-1.74","upperLimit":"6.29","value":"2.28"}]}],"title":"Social Functioning"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-0.66","upperLimit":"11.86","value":"5.60"},{"groupId":"OG001","lowerLimit":"3.71","upperLimit":"12.58","value":"8.15"},{"groupId":"OG002","lowerLimit":"-2.78","upperLimit":"5.80","value":"1.51"}]}],"title":"Emotional Functioning"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.56","upperLimit":"12.87","value":"6.71"},{"groupId":"OG001","lowerLimit":"0.35","upperLimit":"11.14","value":"5.75"},{"groupId":"OG002","lowerLimit":"1.33","upperLimit":"10.47","value":"5.90"}]}],"title":"Physical Functioning"}],"denoms":[{"counts":[{"groupId":"OG000","value":"50"},{"groupId":"OG001","value":"56"},{"groupId":"OG002","value":"58"}],"units":"Participants"}],"description":"The PedsQL consists of a 23-item core measure of global QOL that can be completed in approximately 5 minutes. There is a total score and four subscales: physical functioning, emotional functioning, social functioning and school/work functioning. Participants ≥ 5 years of age complete an age-appropriate self-report; and parents/guardians of children ages 2-17 complete a parent proxy report of the age-specific QOL. The recall period is 7 days. PedsQL items are answered on a Likert scale with responses ranging from 0 to 4 (where 0 means it is never a problem and 4 means it is almost always a problem). These items are then reverse scored and linearly transformed to a 0-100 scale as follows: 0=100, 1=75, 2=50, 3=25, 4=0. On this scale, higher scores indicate better outcomes. Overall scale scores are calculated as the mean of the scores for the questions in said scale (or of all questions for the total score). The change from baseline is modelled using a mixed-model for repeated measures.","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients self-reported results aged 5 to 17 years old at the time of informed consent. Mirdametinib (PD-0325901) capsule or dispersible tablet 2 mg/m\\^2 (maximum dose of 4 mg) by mouth twice daily","id":"OG000","title":"Treatment Phase - Pediatric Cohort Mirdametinib (PD-0325901) - Self-Report"},{"description":"Patients parent proxy results aged 2 to 17 years old at the time of informed consent. Mirdametinib (PD-0325901) capsule or dispersible tablet 2 mg/m\\^2 (maximum dose of 4 mg) by mouth twice daily","id":"OG001","title":"Treatment Phase - Pediatric Cohort Mirdametinib (PD-0325901) - Parent Proxy"},{"description":"Patients self-reported results aged 18 years and above at the time of informed consent. Mirdametinib (PD-0325901) capsule or dispersible tablet 2 mg/m\\^2 (maximum dose of 4 mg) by mouth twice daily","id":"OG002","title":"Treatment Phase - Adult Cohort Mirdametinib (PD-0325901) - Self-Report"}],"paramType":"LEAST_SQUARES_MEAN","populationDescription":"The Full Analysis Set patients who are eligible for the Peds-QL assessments at baseline.","reportingStatus":"POSTED","timeFrame":"Baseline and Cycle 13 (1 cycle = 28 days), up to 12 months","title":"Change From Baseline on Quality of Life (QOL) as Measured by the Pediatric Quality of Life Inventory (PedsQL) at Cycle 13, Acute Version.","type":"SECONDARY","unitOfMeasure":"units on a scale"}