{"classes":[{"title":"Fine Structural Analysis Trabecular Wall Thickness"},{"title":"Fine Structural Analysis Trabecular Wall Separation"}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"description":"* Osteotronix' fineSA® (Fine Structural Analysis, FSA) technology extracts microstructural information from Magnetic Resonance Imaging (MRI) data sets, as a correlate of trabecular wall thickness, to indicate bone remodelling. The FSA metric has been shown to correlate tightly with gold standard bone density measurements in rats \\[Evans et al, 2014\\] and human cadaveric spine specimens \\[Rafferty et al, 2016\\].\n* In this study, we had collected data during the novel MR protocol at both baseline and follow-up time points. However, we were unable to complete analysis of the FSA metrics, because of disruptions due to COVID-19, therefore the results have not been possible to report.","groups":[{"description":"Group 1a: New Myeloma; Group 1b: Relapsed Myeloma Group;1c: Smouldering Myeloma\n\nBaseline AND Follow-Up Assessment:\n\nNovel MR Whole body DXA scan Blood and urine samples QOL \\& scan experience questionnaires","id":"OG000","title":"Group 1- Myeloma"},{"description":"Baseline AND Follow-Up Assessment:\n\nNovel MR Whole body DXA scan Blood and urine samples QOL \\& scan experience questionnaires","id":"OG001","title":"Group 2- MGUS"},{"description":"Baseline Assessment ONLY:\n\n* Novel MR\n* QOL \\& scan experience questionnaires","id":"OG002","title":"Group 3- Healthy Volunteers"}],"populationDescription":"\\- In this study, we had collected data during the novel MR protocol at both baseline and follow-up time points. However, we were unable to complete analysis of the FSA metrics as the company we contracted to undertake this was dissolved, an alternative is not available and there is no remaining budget. Therefore the results will never be possible to report.","reportingStatus":"POSTED","timeFrame":"At baseline","title":"Primary Outcome 1+2: Quantifying Tumour Burden [Osteotronix Fine Structural Analysis (FSA), Trabecular Wall Thickness]","type":"PRIMARY"}