{"classes":[{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG000","spread":"NA","value":"1.00"},{"groupId":"OG001","spread":"0.45","value":"0.56"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12D Cycle 1"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG000","spread":"NA","value":"0.60"},{"groupId":"OG001","spread":"0.49","value":"0.59"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12D Cycle 2"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG000","spread":"NA","value":"1.45"},{"groupId":"OG001","spread":"0.28","value":"0.76"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12D Cycle 3"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.80","value":"1.35"},{"groupId":"OG002","spread":"0.48","value":"2.08"},{"groupId":"OG003","spread":"0.82","value":"1.70"},{"groupId":"OG004","spread":"0.82","value":"2.14"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"3"}],"units":"Participants"}],"title":"KRAS G12D Cycle 4"},{"categories":[{"measurements":[{"groupId":"OG002","spread":"0.40","value":"2.34"},{"groupId":"OG003","spread":"0.53","value":"2.30"},{"groupId":"OG004","spread":"0.15","value":"2.34"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"2"}],"units":"Participants"}],"title":"KRAS G12D Cycle 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.34","value":"0.54"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12D Discontinuation Visit"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.53","value":"0.59"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12V Cycle 1"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG000","spread":"NA","value":"0.90"},{"groupId":"OG001","spread":"0.27","value":"0.12"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12V Cycle 2"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.54","value":"0.88"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12V Cycle 3"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.14","value":"1.84"},{"groupId":"OG002","spread":"1.17","value":"2.04"},{"groupId":"OG003","spread":"0.67","value":"1.94"},{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG004","spread":"NA","value":"2.25"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"1"}],"units":"Participants"}],"title":"KRAS G12V Cycle 4"},{"categories":[{"measurements":[{"groupId":"OG002","spread":"1.43","value":"1.64"},{"groupId":"OG003","spread":"0.21","value":"1.77"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12V Cycle 6"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG001","spread":"NA","value":"2.20"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12V Cycle 7"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG001","spread":"NA","value":"2.20"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12V Cycle 9"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.04","value":"1.45"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12V Discontinuation Visit"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.67","value":"0.78"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12C Cycle 1"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG000","spread":"NA","value":"0.00"},{"groupId":"OG001","spread":"0.85","value":"0.60"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12C Cycle 2"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.70","value":"1.10"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12C Cycle 3"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.72","value":"1.93"},{"groupId":"OG002","spread":"1.18","value":"2.07"},{"groupId":"OG003","spread":"0.89","value":"2.12"},{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG004","spread":"NA","value":"2.45"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"1"}],"units":"Participants"}],"title":"KRAS G12C Cycle 4"},{"categories":[{"measurements":[{"groupId":"OG002","spread":"1.29","value":"1.93"},{"groupId":"OG003","spread":"0.68","value":"2.24"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12C Cycle 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.35","value":"1.55"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G12C Discontinuation Visit"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.49","value":"0.65"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G13D Cycle 1"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG000","spread":"NA","value":"0.00"},{"groupId":"OG001","spread":"0.56","value":"0.62"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G13D Cycle 2"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.87","value":"0.91"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G13D Cycle 3"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.71","value":"1.92"},{"groupId":"OG002","spread":"1.02","value":"1.53"},{"groupId":"OG003","spread":"0.20","value":"1.48"},{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG004","spread":"NA","value":"1.26"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"1"}],"units":"Participants"}],"title":"KRAS G13D Cycle 4"},{"categories":[{"measurements":[{"groupId":"OG002","spread":"1.12","value":"1.60"},{"groupId":"OG003","spread":"0.05","value":"1.75"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G13D Cycle 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.87","value":"0.92"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"KRAS G13D Discontinuation Visit"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG000","spread":"NA","value":"1.08"},{"groupId":"OG001","spread":"0.54","value":"0.24"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"Wild Type Cycle 1"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG000","spread":"NA","value":"0.00"},{"groupId":"OG001","spread":"0.60","value":"0.49"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"10"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"Wild Type Cycle 2"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG000","spread":"NA","value":"1.15"},{"groupId":"OG001","spread":"0.60","value":"0.86"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"Wild Type Cycle 3"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"0.59","value":"1.79"},{"groupId":"OG002","spread":"0.59","value":"1.64"},{"groupId":"OG003","spread":"0.47","value":"1.56"},{"groupId":"OG004","spread":"0.59","value":"1.26"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"7"},{"groupId":"OG004","value":"3"}],"units":"Participants"}],"title":"Wild Type Cycle 4"},{"categories":[{"measurements":[{"groupId":"OG002","spread":"1.01","value":"1.38"},{"groupId":"OG003","spread":"0.24","value":"1.88"},{"groupId":"OG004","spread":"0.08","value":"1.59"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"2"}],"units":"Participants"}],"title":"Wild Type Cycle 6"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG001","spread":"NA","value":"2.33"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"Wild Type Cycle 7"},{"categories":[{"measurements":[{"comment":"Standard deviation was not calculatable when n\\<2.","groupId":"OG001","spread":"NA","value":"1.95"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"Wild Type Cycle 9"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.71","value":"0.80"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"Wild Type Discontinuation Visit"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"11"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"7"},{"groupId":"OG004","value":"3"}],"units":"Participants"}],"description":"The presence of mutant KRAS specific T cells (G12D, G12V, G13D, G12C, and Wild type) in blood was assessed using an enzyme linked immunosorbent spot (ELISpot) assay. ELISpot detects interferon gamma (IFN-g) producing T-cells in a participant's peripheral blood mononuclear cells (PBMC) in response to KRAS specific stimulation. Data are presented as spot forming cells (SFC) per 10\\^6 PBMC. The post-treatment ELISpot readout for a cycle is reported. A cycle is 3 weeks.","dispersionType":"Standard Deviation","groups":[{"description":"V941(mRNA-5671/V941) 1 mg administered intramuscularly (IM) once every 3 weeks (Q3W) for 9 3-week cycles","id":"OG000","title":"Part 1: V941 Monotherapy"},{"description":"V941(mRNA-5671/V941) 1 mg administered IM Q3W for 9 3-week cycles and pembrolizumab 200 mg, intravenous (IV) for 35 3-week cycles","id":"OG001","title":"Part 1: V941 + Pembrolizumab"},{"description":"V941(mRNA-5671/V941) 1 mg administered IM Q3W for 9 3-week cycles and pembrolizumab 200 mg, IV for 35 3-week cycles","id":"OG002","title":"Part 2: Expansion Cohort 1 Non-small Cell Lung Cancer (V941 + Pembrolizumab)"},{"description":"V941(mRNA-5671/V941) 1 mg administered IM Q3W for 9 3-week cycles and pembrolizumab 200 mg, IV for 35 3-week cycles","id":"OG003","title":"Part 2: Expansion Cohort 2 Colorectal Cancer (V941 + Pembrolizumab)"},{"description":"V941(mRNA-5671/V941) 1 mg administered IM Q3W for 9 3-week cycles and pembrolizumab 200 mg, IV for 35 3-week cycles","id":"OG004","title":"Part 2: Expansion Cohort 3 Pancreatic Adenocarcinoma (V941 + Pembrolizumab)"}],"paramType":"MEAN","populationDescription":"Participants with centrally-confirmed tumor KRAS mutations, with a baseline scan that demonstrated measurable disease and who received at least 1 dose of study treatment. The number of participants analyzed indicates a pre-treatment ELISpot readout for a cycle and a post-treatment ELISpot readout for a cycle, which are required for a participant's data to be reported for a particular cycle. A cycle is 3 weeks.","reportingStatus":"POSTED","timeFrame":"Cycle 1 - Cycle 9 (a cycle is 3 weeks) and at the Discontinuation Visit (at the time of withdrawal or up to 30 weeks, whichever occurs first)","title":"Presence of Mutant Kirsten Rat Sarcoma (KRAS) Specific T Cells","type":"SECONDARY","unitOfMeasure":"Log10(IFN-g (SFC per 10^6 PBMC))"}