{"denoms":[{"counts":[{"groupId":"OG000","value":"0"}],"units":"Participants"}],"description":"Time to next treatment (TNT) is defined as the time from the date of enrollment to the institution of next treatment.","groups":[{"description":"Nivolumab is a human monoclonal antibody (HuMAb; immunoglobulin G4 \\[IgG4\\]-S228P) that targets the programmed death-1 (PD-1) cluster of differentiation 279 (CD279) cell surface membrane receptor. PD-1 is a negative regulatory molecule expressed by activated T and B lymphocytes.1 Binding of PD-1 to its ligands, programmed death-ligands 1 (PD-L1) and 2 (PD-L2), results in the down-regulation of lymphocyte activation. Inhibition of the interaction between PD-1 and its ligands promotes immune responses and antigen-specific T-cell responses to both foreign antigens as well as self-antigens. Nivolumab will be delivered intravenously at a fixed dose of 240 mg on day 1 of 14 day cycles.\n\nCabiralizumab is a recombinant, humanized Immunoglobulin G4 (IgG4) monoclonal antibody that binds to human colony stimulating factor 1 receptor (CSF1R; c-fms). Cabiralizumab will be delivered intravenously at a dosage of 4 mg/kg on day 1 of 14 day cycles.","id":"OG000","title":"Nivolumab + Cabiralizumab"}],"populationDescription":"Data was not collected. Study was conducted through BTCRC and was not collected. No data is available to be analyzed and will never become available.","reportingStatus":"POSTED","timeFrame":"Up to 1 year post discontinuation of therapy, average of 24 months","title":"Time to Next Treatment (TNT)","type":"SECONDARY"}