{"classes":[{"categories":[{"measurements":[{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG001","spread":"NA","value":"NA"},{"groupId":"OG002","spread":"77.5","value":"56.6"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"Geometric Coefficient of Variation not calculable for a single participant (one participant's concentrations were below limit of 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including values below the limit of quantification","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"Geometric Coefficient of Variation not calculable for a single participant","groupId":"OG002","spread":"NA","value":"68.8"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG004","spread":"NA","value":"NA"},{"groupId":"OG005","spread":"47.4","value":"3410"},{"groupId":"OG006","spread":"43.5","value":"11600"},{"groupId":"OG007","spread":"38.9","value":"40800"},{"groupId":"OG008","spread":"40.5","value":"130000"},{"groupId":"OG009","spread":"31.5","value":"325000"},{"groupId":"OG010","spread":"21.2","value":"1100000"},{"groupId":"OG011","spread":"16.9","value":"1390000"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"3"},{"groupId":"OG006","value":"7"},{"groupId":"OG007","value":"12"},{"groupId":"OG008","value":"9"},{"groupId":"OG009","value":"3"},{"groupId":"OG010","value":"4"},{"groupId":"OG011","value":"2"}],"units":"Participants"}],"title":"Cycle 1 Day 15"},{"categories":[{"measurements":[{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG004","spread":"NA","value":"NA"},{"groupId":"OG005","spread":"35.7","value":"3240"},{"groupId":"OG006","spread":"43.7","value":"10800"},{"groupId":"OG007","spread":"24.1","value":"36800"},{"groupId":"OG008","spread":"15.3","value":"103000"},{"groupId":"OG009","spread":"28.2","value":"388000"},{"groupId":"OG010","spread":"29.7","value":"1160000"},{"groupId":"OG011","spread":"15.0","value":"1560000"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"3"},{"groupId":"OG006","value":"4"},{"groupId":"OG007","value":"5"},{"groupId":"OG008","value":"5"},{"groupId":"OG009","value":"2"},{"groupId":"OG010","value":"4"},{"groupId":"OG011","value":"2"}],"units":"Participants"}],"title":"Cycle 2 Day 1 (Schedule 1 only)"},{"categories":[{"measurements":[{"groupId":"OG006","spread":"16.1","value":"11500"},{"groupId":"OG007","spread":"58.5","value":"33600"},{"groupId":"OG008","spread":"35.2","value":"145000"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"},{"groupId":"OG005","value":"0"},{"groupId":"OG006","value":"3"},{"groupId":"OG007","value":"6"},{"groupId":"OG008","value":"3"},{"groupId":"OG009","value":"0"},{"groupId":"OG010","value":"0"},{"groupId":"OG011","value":"0"}],"units":"Participants"}],"title":"Cycle 2 Day 1 (Schedule 2 only)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"3"},{"groupId":"OG006","value":"8"},{"groupId":"OG007","value":"12"},{"groupId":"OG008","value":"9"},{"groupId":"OG009","value":"4"},{"groupId":"OG010","value":"4"},{"groupId":"OG011","value":"2"}],"units":"Participants"}],"description":"The AUC is the area under the serum concentration time curve following single and multiple doses of SL-279252. AUC (0-inf; from time 0 to infinity) is reported for C1D1 and C2D1 (Schedule 1 only); AUC (tau; over a dosing interval) is reported for C1D15 and C2D1 (Schedule 2 only).","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"0.0001 mg/kg of IV SL-279252 (Schedule 1)","id":"OG000","title":"SL-279252 (0.0001 mg/kg S1)"},{"description":"0.001 mg/kg of IV SL-279252 (Schedule 1)","id":"OG001","title":"SL-279252 (0.001 mg/kg S1)"},{"description":"0.003 mg/kg of IV SL-279252 (Schedule 1)","id":"OG002","title":"SL-279252 (0.003 mg/kg S1)"},{"description":"0.01 mg/kg of IV SL-279252 (Schedule 1)","id":"OG003","title":"SL-279252 (0.01 mg/kg S1)"},{"description":"0.03 mg/kg of IV SL-279252 (Schedule 1)","id":"OG004","title":"SL-279252 (0.03 mg/kg S1)"},{"description":"0.1 mg/kg of IV SL-279252 (Schedule 1)","id":"OG005","title":"SL-279252 (0.1 mg/kg S1)"},{"description":"0.3 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)","id":"OG006","title":"SL-279252 (0.3 mg/kg S1 or S2)"},{"description":"1.0 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)","id":"OG007","title":"SL-279252 (1.0 mg/kg S1 or S2)"},{"description":"3.0 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)","id":"OG008","title":"SL-279252 (3.0 mg/kg S1 or S2)"},{"description":"6.0 mg/kg of IV SL-279252 (Schedule 1)","id":"OG009","title":"SL-279252 (6.0 mg/kg S1)"},{"description":"12.0 mg/kg of IV SL-279252 (Schedule 1)","id":"OG010","title":"SL-279252 (12.0 mg/kg S1)"},{"description":"24.0 mg/kg of IV SL-279252 (Schedule 1)","id":"OG011","title":"SL-279252 (24.0 mg/kg S1)"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"PK Population - number analyzed may be less than the number of participants in a given cohort if samples were below the limit of quantitation or not available for analysis.","reportingStatus":"POSTED","timeFrame":"Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (cycle = 28 days)","title":"Area Under the Serum Concentration-time Curve (AUC)","type":"SECONDARY","unitOfMeasure":"hours*ng/mL"}