{"classes":[{"categories":[{"measurements":[{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG002","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG003","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG004","spread":"NA","value":"NA"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG005","spread":"NA","value":"NA"},{"groupId":"OG006","spread":"71.9","value":"1.03"},{"groupId":"OG007","spread":"56.5","value":"3.77"},{"groupId":"OG008","spread":"124","value":"10.4"},{"groupId":"OG009","spread":"43.0","value":"29.0"},{"groupId":"OG010","spread":"100","value":"90.7"},{"comment":"Geometric Coefficient of Variation not calculable for a single participant","groupId":"OG011","spread":"NA","value":"12.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"3"},{"groupId":"OG006","value":"7"},{"groupId":"OG007","value":"12"},{"groupId":"OG008","value":"9"},{"groupId":"OG009","value":"3"},{"groupId":"OG010","value":"4"},{"groupId":"OG011","value":"1"}],"units":"Participants"}],"title":"Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG006","spread":"75.2","value":"1.12"},{"comment":"Not estimable based on subjects' concentration profiles, including values below the limit of quantification","groupId":"OG007","spread":"NA","value":"NA"},{"groupId":"OG008","spread":"164","value":"11.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"},{"groupId":"OG005","value":"0"},{"groupId":"OG006","value":"3"},{"groupId":"OG007","value":"6"},{"groupId":"OG008","value":"3"},{"groupId":"OG009","value":"0"},{"groupId":"OG010","value":"0"},{"groupId":"OG011","value":"0"}],"units":"Participants"}],"title":"Cycle 2 Day 1 (Schedule 2 only)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"3"},{"groupId":"OG006","value":"7"},{"groupId":"OG007","value":"12"},{"groupId":"OG008","value":"9"},{"groupId":"OG009","value":"3"},{"groupId":"OG010","value":"4"},{"groupId":"OG011","value":"1"}],"units":"Participants"}],"description":"The Cmin is the minimum observed serum concentration of SL-279252 following single and multiple doses","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"0.0001 mg/kg of IV SL-279252 (Schedule 1)","id":"OG000","title":"SL-279252 (0.0001 mg/kg S1)"},{"description":"0.001 mg/kg of IV SL-279252 (Schedule 1)","id":"OG001","title":"SL-279252 (0.001 mg/kg S1)"},{"description":"0.003 mg/kg of IV SL-279252 (Schedule 1)","id":"OG002","title":"SL-279252 (0.003 mg/kg S1)"},{"description":"0.01 mg/kg of IV SL-279252 (Schedule 1)","id":"OG003","title":"SL-279252 (0.01 mg/kg S1)"},{"description":"0.03 mg/kg of IV SL-279252 (Schedule 1)","id":"OG004","title":"SL-279252 (0.03 mg/kg S1)"},{"description":"0.1 mg/kg of IV SL-279252 (Schedule 1)","id":"OG005","title":"SL-279252 (0.1 mg/kg S1)"},{"description":"0.3 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)","id":"OG006","title":"SL-279252 (0.3 mg/kg S1 or S2)"},{"description":"1.0 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)","id":"OG007","title":"SL-279252 (1.0 mg/kg S1 or S2)"},{"description":"3.0 mg/kg of IV SL-279252 (Schedule 1 or Schedule 2)","id":"OG008","title":"SL-279252 (3.0 mg/kg S1 or S2)"},{"description":"6.0 mg/kg of IV SL-279252 (Schedule 1)","id":"OG009","title":"SL-279252 (6.0 mg/kg S1)"},{"description":"12.0 mg/kg of IV SL-279252 (Schedule 1)","id":"OG010","title":"SL-279252 (12.0 mg/kg S1)"},{"description":"24.0 mg/kg of IV SL-279252 (Schedule 1)","id":"OG011","title":"SL-279252 (24.0 mg/kg S1)"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"PK Population - number analyzed may be less than the number of participants in a given cohort if samples were below the limit of quantitation or not available for analysis.","reportingStatus":"POSTED","timeFrame":"Cycle 1 Day 15 and Cycle 2 Day 1 (cycle = 28 days)","title":"Minimum Serum Concentration (Cmin) of SL-279252","type":"SECONDARY","unitOfMeasure":"ng/mL"}