{"analyses":[{"ciLowerLimit":"0.4","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"6.2","estimateComment":"Based on a mixed effect model analysis, with QLQ-C30 scores until cycle 18 as the response variable, and treatment by study visit interaction, Baseline mean score, and randomization stratification factors as covariates.","groupDescription":"Analysis of Change from Baseline in Global Health Status/QoL at Cycle 6","groupIds":["OG000","OG001"],"nonInferiorityType":"OTHER","paramType":"LS Mean Difference","paramValue":"3.3"},{"ciLowerLimit":"0.0","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"5.1","estimateComment":"Based on a mixed effect model analysis, with QLQ-C30 scores until cycle 18 as the response variable, and treatment by study visit interaction, Baseline mean score, and randomization stratification factors as covariates.","groupDescription":"Analysis of Change from Baseline in Physical Functioning at Cycle 6","groupIds":["OG000","OG001"],"nonInferiorityType":"OTHER","paramType":"LS Mean Difference","paramValue":"2.6"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-2.3","upperLimit":"1.8","value":"-0.3"},{"groupId":"OG001","lowerLimit":"-5.8","upperLimit":"-1.4","value":"-3.6"}]}],"title":"Global Health Status/ QOL"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-6.6","upperLimit":"-3.0","value":"-4.8"},{"groupId":"OG001","lowerLimit":"-9.2","upperLimit":"-5.4","value":"-7.3"}]}],"title":"Physical Functioning"}],"denoms":[{"counts":[{"groupId":"OG000","value":"310"},{"groupId":"OG001","value":"309"}],"units":"Participants"}],"description":"The EORTC QLQ-30 contains 30 questions that incorporate 5 functional scales (physical functioning, role functioning, emotional functioning, cognitive functioning, and social functioning), 1 global health status scale, 3 symptom scales (fatigue, nausea and vomiting, and pain), and 6 single items (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). The participant answers questions about their health during the past week. There are 28 questions answered on a 4-point scale where 1 = Not at all (best) and 4 = Very Much (worst) and 2 global health quality of life (QOL) questions answered on a 7-point scale where 1 = Very poor and 7 = Excellent. Raw scores are transformed to a 0 to 100 scale via linear transformation. Higher scores in GHS and functional scales indicate better quality of life.","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants received tislelizumab 200 mg administered IV on Day 1 of each 3-week treatment cycle together with an investigator-chosen chemotherapy doublet until unacceptable toxicity, disease progression or withdrawal for other reasons.","id":"OG000","title":"Tislelizumab + Chemotherapy"},{"description":"Participants received placebo administered IV on Day 1 of each 3-week treatment cycle together with an investigator-chosen chemotherapy doublet until unacceptable toxicity, disease progression or withdrawal for other reasons.","id":"OG001","title":"Placebo + Chemotherapy"}],"paramType":"LEAST_SQUARES_MEAN","populationDescription":"Participants in the ITT Analysis Set who completed the EORTC QLQ-C30 at Baseline and at least one post-baseline measurement.","reportingStatus":"POSTED","timeFrame":"Baseline, Cycle 6 (Week 15)","title":"Change From Baseline in European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire - Core 30 (QLQ-C30) Global Health Status/Quality of Life (GHS/QoL) and Physical Functioning Scales","type":"SECONDARY","unitOfMeasure":"score on a scale"}