{"classes":[{"categories":[{"measurements":[{"comment":"The data was not evaluable as all the samples were below lower limit of quantification (BLLQ).","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"The data was not evaluable as all the samples were BLLQ.","groupId":"OG001","spread":"NA","value":"NA"},{"comment":"The data was not evaluable as all the samples were BLLQ.","groupId":"OG002","spread":"NA","value":"NA"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"39"}],"units":"Participants"}],"title":"Cycle 1, Day 1: Pre-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"57.8","value":"116"},{"groupId":"OG001","spread":"70.9","value":"61.7"},{"groupId":"OG002","spread":"57.6","value":"108"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"39"}],"units":"Participants"}],"title":"Cycle 1, Day 1: Post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"40.5","value":"247"},{"groupId":"OG001","spread":"44.3","value":"123"},{"groupId":"OG002","spread":"45.7","value":"166"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"38"}],"units":"Participants"}],"title":"Cycle 1, Day 3: Post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"36.6","value":"230"},{"groupId":"OG001","spread":"45.0","value":"110"},{"groupId":"OG002","spread":"43.5","value":"162"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"37"}],"units":"Participants"}],"title":"Cycle 1, Day 8: Post-dose"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"51.4","value":"77.5"},{"groupId":"OG002","spread":"88.6","value":"78.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"35"}],"units":"Participants"}],"title":"Cycle 2, Day 1: Pre-dose"},{"categories":[{"measurements":[{"groupId":"OG002","spread":"64.7","value":"87.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"36"}],"units":"Participants"}],"title":"Cycle 2, Day 1: Post-dose"},{"categories":[{"measurements":[{"groupId":"OG002","spread":"46.1","value":"183"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"36"}],"units":"Participants"}],"title":"Cycle 2, Day 2: Post-dose"},{"categories":[{"measurements":[{"groupId":"OG002","spread":"42.0","value":"245"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"34"}],"units":"Participants"}],"title":"Cycle 2, Day 4: Post-dose"},{"categories":[{"measurements":[{"groupId":"OG002","spread":"37.2","value":"225"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"35"}],"units":"Participants"}],"title":"Cycle 2, Day 9: Post-dose"},{"categories":[{"measurements":[{"groupId":"OG001","spread":"47.8","value":"104"},{"groupId":"OG002","spread":"57.2","value":"123"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"33"}],"units":"Participants"}],"title":"Cycle 3, Day 1: Pre-dose"},{"categories":[{"measurements":[{"comment":"Since only 1 participant was analysed the geometric coefficient of variation could not be calculated.","groupId":"OG001","spread":"NA","value":"189"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}],"units":"Participants"}],"title":"Cycle 3, Day 1: Post-dose"}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"15"},{"groupId":"OG002","value":"39"}],"units":"Participants"}],"description":"Cycle length =21 days for cohorts 1 and 3 and 14 days for cohort 2. Day=D; Cycle=C.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants received atezolizumab, 1800 mg, co-mixed with rHuPH20, as SC injection on Cycle 1 Day 1 (1 cycle=21 days), followed by atezolizumab, 1200 mg, as an IV infusion, Q3W on Day 1 of subsequent cycles (1 cycle=21 days) until PD, loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.","id":"OG000","title":"Part 1 Cohort 1: Atezolizumab SC Co-mix 1800 mg"},{"description":"Participants received atezolizumab, 1200 mg, co-mixed with rHuPH20, as SC injection, Q2W, on Day 1 of the first 3 cycles (Cycle 1-3=14 days), followed by atezolizumab, 1200 mg, as an IV infusion, Q3W, on Day 1 of subsequent cycles (1 cycle=21 days) until PD, loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.","id":"OG001","title":"Part 1 Cohort 2: Atezolizumab SC Co-mix 1200 mg"},{"description":"Participants received atezolizumab, 1800 mg, co-mixed with rHuPH20, as SC injection, Q3W, on Day 1 of first 3 cycles, followed by atezolizumab, 1200 mg, as an IV infusion, Q3W on Day 1 for subsequent cycles (1 cycle=21 days) until PD, loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.","id":"OG002","title":"Part 1 Cohort 3: Atezolizumab SC Co-mix 1800 mg"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"PK-evaluable population included all participants who received at least one dose of atezolizumab and had at least 1 evaluable post dose PK sample that could affect PK results. Overall number analyzed is the number of participants with data available for analysis. Number analyzed is the number of participants with data available for analysis at a given timepoint.","reportingStatus":"POSTED","timeFrame":"Cohort 1: Predose: D1 & postdose: D1, 3, 8 of C1; Cohort 2: Pre & postdose: D1 of C1, 3 & postdose: D3, 8 of C1, Predose: D1 of C2; Cohort 3: Pre & postdose: D1 of C1, 2 & postdose: D3, 8 of C1, D2, 4 & 9 of C2 & pre dose: D1 of C3","title":"Part 1: Serum Atezolizumab Concentration at Specified Timepoint During SC Administration","type":"SECONDARY","unitOfMeasure":"μg/mL"}