{"denoms":[{"counts":[{"groupId":"BG000","value":"327"},{"groupId":"BG001","value":"325"},{"groupId":"BG002","value":"652"}],"units":"Participants"}],"groups":[{"description":"Participants received 160 mg zanubrutinib orally twice daily until disease progression, intolerable toxicity, initiation of alternative anticancer therapy, investigator/Sponsor decision, need for prohibited medication, study withdrawal, or pregnancy.","id":"BG000","title":"Zanubrutinib"},{"description":"Participants received ibrutinib 420 mg orally once daily until disease progression, intolerable toxicity, initiation of alternative anticancer therapy, investigator/Sponsor decision, need for prohibited medication, study withdrawal, or pregnancy.","id":"BG001","title":"Ibrutinib"},{"description":"Total of all reporting groups","id":"BG002","title":"Total"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"}],"title":"<=18 years"},{"measurements":[{"groupId":"BG000","value":"126"},{"groupId":"BG001","value":"125"},{"groupId":"BG002","value":"251"}],"title":"Between 18 and 65 years"},{"measurements":[{"groupId":"BG000","value":"201"},{"groupId":"BG001","value":"200"},{"groupId":"BG002","value":"401"}],"title":">=65 years"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Age, Categorical","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"35","upperLimit":"90","value":"67.0"},{"groupId":"BG001","lowerLimit":"35","upperLimit":"89","value":"68.0"},{"groupId":"BG002","lowerLimit":"35","upperLimit":"90","value":"67.0"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Age, Continuous","unitOfMeasure":"years"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"114"},{"groupId":"BG001","value":"93"},{"groupId":"BG002","value":"207"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"213"},{"groupId":"BG001","value":"232"},{"groupId":"BG002","value":"445"}],"title":"Male"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"7"},{"groupId":"BG001","value":"13"},{"groupId":"BG002","value":"20"}],"title":"Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"309"},{"groupId":"BG001","value":"298"},{"groupId":"BG002","value":"607"}],"title":"Not Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"11"},{"groupId":"BG001","value":"14"},{"groupId":"BG002","value":"25"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Ethnicity (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"47"},{"groupId":"BG001","value":"44"},{"groupId":"BG002","value":"91"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"4"},{"groupId":"BG001","value":"2"},{"groupId":"BG002","value":"6"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"3"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"3"}],"title":"Native Hawaiian or Pacific Islander"},{"measurements":[{"groupId":"BG000","value":"261"},{"groupId":"BG001","value":"265"},{"groupId":"BG002","value":"526"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"2"},{"groupId":"BG002","value":"4"}],"title":"Other"},{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"1"}],"title":"Multiple"},{"measurements":[{"groupId":"BG000","value":"9"},{"groupId":"BG001","value":"12"},{"groupId":"BG002","value":"21"}],"title":"Unknown/Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race/Ethnicity, Customized","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"49"},{"groupId":"BG001","value":"45"},{"groupId":"BG002","value":"94"}],"title":"Asia"},{"measurements":[{"groupId":"BG000","value":"28"},{"groupId":"BG001","value":"30"},{"groupId":"BG002","value":"58"}],"title":"Australia/New Zealand"},{"measurements":[{"groupId":"BG000","value":"198"},{"groupId":"BG001","value":"191"},{"groupId":"BG002","value":"389"}],"title":"Europe"},{"measurements":[{"groupId":"BG000","value":"52"},{"groupId":"BG001","value":"59"},{"groupId":"BG002","value":"111"}],"title":"North America"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Geographic Region","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"75"},{"groupId":"BG001","value":"75"},{"groupId":"BG002","value":"150"}],"title":"Del(17p) and/or TP53 mutation"},{"measurements":[{"groupId":"BG000","value":"251"},{"groupId":"BG001","value":"250"},{"groupId":"BG002","value":"501"}],"title":"Neither Del(17p) nor TP53 mutation"},{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"1"}],"title":"Missing"}]}],"description":"Deletion 17p is a chromosomal abnormality that occurs when part or all of the short arm of chromosome 17 is lost.\n\nThe TP53 gene provides instructions for making a protein called tumor protein p53 (or p53) which acts as a tumor suppressor.","paramType":"COUNT_OF_PARTICIPANTS","title":"Chromosome 17p Deletion (del[17p]) and TP53 Mutation Status","unitOfMeasure":"Participants"}],"populationDescription":"Intent-to-Treat (ITT) Analysis Set includes all randomized participants"}