{"denoms":[{"counts":[{"groupId":"BG000","value":"264"},{"groupId":"BG001","value":"200"},{"groupId":"BG002","value":"266"},{"groupId":"BG003","value":"730"}],"units":"Participants"}],"groups":[{"description":"Participants received durvalumab monotherapy (1500 mg for participants \\>30 kg in weight and a weight-based dosing equivalent to 20 mg/kg for participants \\<=30 kg in weight) via IV infusion once q4w, until clinical/RECIST 1.1-defined radiological progression, intolerable toxicity, or for a maximum of 24 months, whichever occurred first.","id":"BG000","title":"Durvalumab"},{"description":"Participants received durvalumab in combination with tremelimumab (1500 mg durvalumab in combination with 75 mg tremelimumab for participants \\>30 kg in weight and a weight-based dosing equivalent to 20 mg/kg durvalumab in combination with 1 mg/kg tremelimumab for participants \\<=30 kg in weight) via IV infusion once q4w, until clinical/RECIST 1.1-defined radiological progression, intolerable toxicity, or for a maximum of 24 months, whichever occurred first.","id":"BG001","title":"Durvalumab Plus Tremelimumab"},{"description":"Participants received matching placebo via IV infusion once q4w for 4 doses/cycles each, until clinical/RECIST 1.1-defined radiological progression, intolerable toxicity, or for a maximum of 24 months, whichever occurred first.","id":"BG002","title":"Placebo"},{"description":"Total of all reporting groups","id":"BG003","title":"Total"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"160"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"162"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"<65 years"},{"measurements":[{"groupId":"BG000","value":"104"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"104"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":">=65 years"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Age, Customized","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"86"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"78"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"178"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"188"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"Male"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"130"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"137"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"1"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"3"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"131"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"121"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"2"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"5"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"Other"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race/Ethnicity, Customized","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"8"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"14"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"255"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"249"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"Not Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"1"},{"comment":"Based on the results of the secondary objectives at the interim analysis (reviewed by an unblinded IDMC), data for the D+T arm were to remain blinded to the Sponsor as pre-specified in the study's unblinding plan. Since the D+T arm was blinded at the time of posting the results from this interim analysis, results for that arm will be posted at the time of final analysis.","groupId":"BG001","value":"NA"},{"groupId":"BG002","value":"3"},{"comment":"Total not calculated because data are not available (NA) in one or more arms.","groupId":"BG003","value":"NA"}],"title":"Missing"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race/Ethnicity, Customized","unitOfMeasure":"Participants"}],"populationDescription":"The full analysis set (FAS) included all randomized participants."}