{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"1","value":"17100"},{"groupId":"OG001","spread":"61","value":"14750"}]}],"title":"Cycle 1 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"75","value":"5095"},{"groupId":"OG001","spread":"3","value":"6214"}]}],"title":"Cycle 2 Day 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"description":"AUCinf was defined as area under the plasma concentration-time curve from time zero to infinity.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"PF-06952229 was administered at a dose of 250 mg orally twice daily (BID) for 7 days on, 7 days off for each Cycle (one cycle = 28 days) in combination with enzalutamide at 160 mg orally once a day (QD) as continuous daily dosing.","id":"OG000","title":"Part 1B: PF-06952229 250mg + Enzalutamide"},{"description":"PF-06952229 was administered at a dose of 375 mg orally twice daily (BID) for 7 days on, 7 days off for each Cycle (one cycle = 28 days) in combination with enzalutamide at 160 mg orally QD as continuous daily dosing.","id":"OG001","title":"Part 1B: PF-06952229 375mg + Enzalutamide"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"Participants with mCRPC, conducted dose escalation of PF-06952229 in combination with enzalutamide, who had sufficient information to estimate at least 1 of the PK parameters of interest and contributed to the summary statistics for AUCinf. AUCinf can be evaluated only when a well characterized terminal phase was observed, which is defined as one with at least 3 data points, r\\^2≥0.9, and AUCextrap%≤20. Here, \"number analyzed\" signifies participant evaluable for each row.","reportingStatus":"POSTED","timeFrame":"0 (pre dose), 0.5, 1, 2, 4, 6 and 12 hours (post dose) on Day 1 of cycle 1 and cycle 2","title":"Area Under the Plasma Concentration-Time Profile From Time Zero Extrapolated to Infinite Time (AUCinf) of PF-06952229 (Part 1B)","type":"SECONDARY","unitOfMeasure":"ng*hr/mL"}