{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"2.10","upperLimit":"2.10","value":"2.10"},{"groupId":"OG001","lowerLimit":"3.83","upperLimit":"3.83","value":"3.83"},{"groupId":"OG002","lowerLimit":"2.00","upperLimit":"2.00","value":"2.00"},{"groupId":"OG003","lowerLimit":"1.08","upperLimit":"5.83","value":"2.15"},{"groupId":"OG004","lowerLimit":"1.00","upperLimit":"9.00","value":"2.17"},{"groupId":"OG005","lowerLimit":"0.950","upperLimit":"9.00","value":"2.03"},{"groupId":"OG006","lowerLimit":"1.00","upperLimit":"2.12","value":"1.97"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"13"},{"groupId":"OG005","value":"17"},{"groupId":"OG006","value":"4"}],"units":"Participants"}],"title":"Cycle 1 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.967","upperLimit":"0.967","value":"0.967"},{"groupId":"OG001","lowerLimit":"2.05","upperLimit":"2.05","value":"2.05"},{"groupId":"OG002","lowerLimit":"2.18","upperLimit":"2.18","value":"2.18"},{"groupId":"OG003","lowerLimit":"0.450","upperLimit":"2.38","value":"1.51"},{"groupId":"OG004","lowerLimit":"0","upperLimit":"3.90","value":"2.00"},{"groupId":"OG005","lowerLimit":"0.850","upperLimit":"4.33","value":"1.92"},{"groupId":"OG006","lowerLimit":"1.00","upperLimit":"2.00","value":"1.48"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"15"},{"groupId":"OG006","value":"4"}],"units":"Participants"}],"title":"Cycle 1 Day 7"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"3.95","upperLimit":"3.95","value":"3.95"},{"groupId":"OG001","lowerLimit":"6.08","upperLimit":"6.08","value":"6.08"},{"groupId":"OG002","lowerLimit":"5.52","upperLimit":"5.52","value":"5.52"},{"groupId":"OG003","lowerLimit":"1.00","upperLimit":"6.03","value":"5.99"},{"groupId":"OG004","lowerLimit":"1.03","upperLimit":"5.93","value":"4.14"},{"groupId":"OG005","lowerLimit":"1.00","upperLimit":"9.08","value":"5.02"},{"groupId":"OG006","lowerLimit":"2.00","upperLimit":"9.00","value":"3.65"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"12"},{"groupId":"OG006","value":"4"}],"units":"Participants"}],"title":"Cycle 2 Day 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"13"},{"groupId":"OG005","value":"17"},{"groupId":"OG006","value":"4"}],"units":"Participants"}],"description":"Tmax was defined as time to maximum observed concentration. Observed directly from data as time of first occurrence.","dispersionType":"Full Range","groups":[{"description":"PF-06952229 was administered at a dose of 20 mg orally twice daily (BID) for 7 days on, 7 days off for each Cycle (one cycle = 28 days).","id":"OG000","title":"Part 1A: PF-06952229 20mg Monotherapy"},{"description":"PF-06952229 was administered at a dose of 40 mg orally BID for 7 days on, 7 days off for each Cycle (one cycle = 28 days).","id":"OG001","title":"Part 1A: PF-06952229 40mg Monotherapy"},{"description":"PF-06952229 was administered at a dose of 80 mg orally BID for 7 days on, 7 days off for each Cycle (one cycle = 28 days).","id":"OG002","title":"Part 1A: PF-06952229 80mg Monotherapy"},{"description":"PF-06952229 was administered at a dose of 150 mg orally BID for 7 days on, 7 days off for each Cycle (one cycle = 28 days).","id":"OG003","title":"Part 1A: PF-06952229 150mg Monotherapy"},{"description":"PF-06952229 was administered at a dose of 250 mg orally BID for 7 days on, 7 days off for each Cycle (one cycle = 28 days).","id":"OG004","title":"Part 1A: PF-06952229 250mg Monotherapy"},{"description":"PF-06952229 was administered at a dose of 375 mg orally BID for 7 days on, 7 days off for each Cycle (one cycle = 28 days).","id":"OG005","title":"Part 1A: PF-06952229 375mg Monotherapy"},{"description":"PF-06952229 was administered at a dose of 500 mg orally BID for 7 days on, 7 days off for each Cycle (one cycle = 28 days).","id":"OG006","title":"Part 1A: PF-06952229 500mg Monotherapy"}],"paramType":"MEDIAN","populationDescription":"Participants with advanced/metastatic tumors in PF-06952229 single agent dose escalation phase, who had sufficient information to estimate at least 1 of the PK parameters of interest. Here, \"number analyzed\" signifies participant evaluable for each row.","reportingStatus":"POSTED","timeFrame":"0 (pre dose), 0.5, 1, 2, 4, 6 and 12 hours (post dose) on Day 1 and 7 of cycle 1, 0 (pre dose), 0.5, 1, 2, 4, 6 and 12 hours (post dose) on Day 1 of cycle 2.","title":"Time of Observed Maximum Plasma Concentration (Tmax) of PF-06952229 (Part 1A)","type":"SECONDARY","unitOfMeasure":"hour (hr)"}