{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"50.2","value":"39.44"},{"groupId":"OG001","spread":"66.0","value":"91.20"},{"groupId":"OG002","spread":"56.7","value":"85.80"},{"groupId":"OG003","spread":"47.5","value":"523.66"},{"groupId":"OG004","spread":"22.7","value":"1298.0"},{"groupId":"OG005","spread":"58.7","value":"1497.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"11"},{"groupId":"OG004","value":"7"},{"groupId":"OG005","value":"6"}],"units":"Participants"}],"title":"AUC(0-inf) Hx-DR5-01 Cycle 1 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"61.5","value":"46.37"},{"groupId":"OG001","spread":"55.8","value":"105.32"},{"groupId":"OG002","spread":"30.5","value":"35.24"},{"groupId":"OG003","spread":"24.8","value":"530.48"},{"groupId":"OG004","spread":"30.7","value":"1071.5"},{"groupId":"OG005","spread":"10.7","value":"2488.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"7"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"2"}],"units":"Participants"}],"title":"AUC(0-inf) Hx-DR5-01 Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"74.0","value":"37.43"},{"groupId":"OG001","spread":"133.3","value":"53.24"},{"groupId":"OG002","spread":"84.9","value":"41.41"},{"groupId":"OG003","spread":"26.8","value":"422.32"},{"groupId":"OG004","spread":"36.6","value":"1097.8"},{"comment":"Geometric coefficient of variation was not derived as only one participant was evaluated for this arm.","groupId":"OG005","spread":"NA","value":"2653.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"1"}],"units":"Participants"}],"title":"AUC(0-inf) Hx-DR5-01 Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"55.4","value":"32.97"},{"groupId":"OG001","spread":"66.9","value":"71.21"},{"groupId":"OG002","spread":"51.7","value":"83.37"},{"groupId":"OG003","spread":"33.0","value":"508.76"},{"groupId":"OG004","spread":"24.7","value":"1052.1"},{"groupId":"OG005","spread":"60.1","value":"1270.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"11"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"6"}],"units":"Participants"}],"title":"AUC(0-inf) Hx-DR5-05 Cycle 1 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"65.9","value":"39.31"},{"groupId":"OG001","spread":"66.6","value":"93.11"},{"groupId":"OG002","spread":"184.4","value":"44.76"},{"groupId":"OG003","spread":"24.1","value":"414.90"},{"groupId":"OG004","spread":"55.2","value":"609.90"},{"groupId":"OG005","spread":"9.0","value":"2273.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"2"}],"units":"Participants"}],"title":"AUC(0-inf) Hx-DR5-05 Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"57.3","value":"25.87"},{"groupId":"OG001","spread":"161.6","value":"51.36"},{"groupId":"OG002","spread":"200.5","value":"67.23"},{"groupId":"OG003","spread":"53.2","value":"231.49"},{"groupId":"OG004","spread":"64.1","value":"412.87"},{"comment":"Geometric coefficient of variation was not derived as only one participant was evaluated for this arm.","groupId":"OG005","spread":"NA","value":"2398.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"1"}],"units":"Participants"}],"title":"AUC(0-inf) Hx-DR5-05 Cycle 3 Day 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"11"},{"groupId":"OG004","value":"7"},{"groupId":"OG005","value":"6"}],"units":"Participants"}],"description":"The AUC(0-inf) of Hx-DR5-01 and Hx-DR5-05 are reported.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants received 0.1 mg/kg of GEN1029 every 2 weeks (Q2W) until the end of treatment.","id":"OG000","title":"Biweekly Regimen (GEN1029 0.1 mg/kg)"},{"description":"Participants received 0.2 mg/kg of GEN1029 Q2W until the end of treatment.","id":"OG001","title":"Biweekly Regimen (GEN1029 0.2 mg/kg)"},{"description":"Participants received 0.3 mg/kg of GEN1029 Q2W until the end of treatment.","id":"OG002","title":"Biweekly Regimen (GEN1029 0.3 mg/kg)"},{"description":"Participants received 1.0 mg/kg of GEN1029 Q2W until the end of treatment.","id":"OG003","title":"Biweekly Regimen (GEN1029 1.0 mg/kg)"},{"description":"Participants received 2.0 mg/kg of GEN1029 Q2W until the end of treatment.","id":"OG004","title":"Biweekly Regimen (GEN1029 2.0 mg/kg)"},{"description":"Participants received 3.0 mg/kg of GEN1029 Q2W until the end of treatment.","id":"OG005","title":"Biweekly Regimen (GEN1029 3.0 mg/kg)"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"PK analysis set included all participants who were exposed to at least 1 dose of GEN1029 and who had at least 1 post-dose PK measurement. 'Number analyzed' denotes the number of participants evaluated for the specified time point.","reportingStatus":"POSTED","timeFrame":"Predose, end of infusion, 2, 4, 24, 48, 168 and 336 hours after end of infusion on Day 1 of Cycles 1, 2, 3","title":"Area Under Plasma Concentration-time Curve From Time Zero to Infinity (AUC[0-inf]) of Hx-DR5-01 and Hx-DR5-05","type":"SECONDARY","unitOfMeasure":"µg*h/mL"}