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Participants responding to SOC are expected to undergo high dose chemotherapy (HDCT) and hematopoietic stem cell transplant (HSCT). 1 cycle = 3 weeks","id":"EG000","otherNumAffected":30,"otherNumAtRisk":30,"seriousNumAffected":21,"seriousNumAtRisk":30,"title":"SOC Arm (Pre-crossover Only)"},{"deathsNumAffected":34,"deathsNumAtRisk":92,"description":"\\[Lymphodepleting chemotherapy (LDC)\\] Fludarabine IV (30 mg/m\\^2/day for 3 days) and cyclophosphamide IV (300 mg/m\\^2/day for 3 days) followed by JCAR017 IV infusion at a dose of 100 x 10\\^6 JCAR017-positive viable transduced T cells (CAR+ T cells) on Day 29 (2 to 7 days after completion of LD chemotherapy)","id":"EG001","otherNumAffected":92,"otherNumAtRisk":92,"seriousNumAffected":43,"seriousNumAtRisk":92,"title":"Liso-cel Arm Only"},{"deathsNumAffected":33,"deathsNumAtRisk":61,"description":"participants received 3 cycles of standard of care (SOC) salvage therapy (R-DHAP, R-ICE and R-GDP) per physician's choice. Participants responding to SOC are expected to undergo high dose chemotherapy (HDCT) and hematopoietic stem cell transplant (HSCT). Participants crossed over to JCAR017 regardless of if they received CAR T therapy or not.","id":"EG002","otherNumAffected":57,"otherNumAtRisk":61,"seriousNumAffected":19,"seriousNumAtRisk":61,"title":"SOC-JCAR017 Arm Pre- and Post-Crossover (All Crossed)"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":20,"numAtRisk":30},{"groupId":"EG001","numAffected":62,"numAtRisk":92},{"groupId":"EG002","numAffected":24,"numAtRisk":61}],"term":"Anaemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":30},{"groupId":"EG001","numAffected":10,"numAtRisk":92},{"groupId":"EG002","numAffected":1,"numAtRisk":61}],"term":"Febrile neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":7,"numAtRisk":30},{"groupId":"EG001","numAffected":17,"numAtRisk":92},{"groupId":"EG002","numAffected":5,"numAtRisk":61}],"term":"Leukopenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":30},{"groupId":"EG001","numAffected":25,"numAtRisk":92},{"groupId":"EG002","numAffected":9,"numAtRisk":61}],"term":"Lymphopenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":14,"numAtRisk":30},{"groupId":"EG001","numAffected":75,"numAtRisk":92},{"groupId":"EG002","numAffected":31,"numAtRisk":61}],"term":"Neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":25,"numAtRisk":30},{"groupId":"EG001","numAffected":54,"numAtRisk":92},{"groupId":"EG002","numAffected":21,"numAtRisk":61}],"term":"Thrombocytopenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":7,"numAtRisk":92},{"groupId":"EG002","numAffected":2,"numAtRisk":61}],"term":"Sinus tachycardia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":30},{"groupId":"EG001","numAffected":9,"numAtRisk":92},{"groupId":"EG002","numAffected":4,"numAtRisk":61}],"term":"Tachycardia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Ear and labyrinth disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":30},{"groupId":"EG001","numAffected":6,"numAtRisk":92},{"groupId":"EG002","numAffected":2,"numAtRisk":61}],"term":"Ear pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Eye disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":30},{"groupId":"EG001","numAffected":6,"numAtRisk":92},{"groupId":"EG002","numAffected":1,"numAtRisk":61}],"term":"Vision blurred"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":6,"numAtRisk":92},{"groupId":"EG002","numAffected":2,"numAtRisk":61}],"term":"Abdominal distension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":30},{"groupId":"EG001","numAffected":13,"numAtRisk":92},{"groupId":"EG002","numAffected":4,"numAtRisk":61}],"term":"Abdominal pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":1,"numAtRisk":92},{"groupId":"EG002","numAffected":0,"numAtRisk":61}],"term":"Abdominal pain upper"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":30},{"groupId":"EG001","numAffected":30,"numAtRisk":92},{"groupId":"EG002","numAffected":10,"numAtRisk":61}],"term":"Constipation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 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26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":3,"numAtRisk":92},{"groupId":"EG002","numAffected":1,"numAtRisk":61}],"term":"Gastrooesophageal reflux disease"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":1,"numAtRisk":92},{"groupId":"EG002","numAffected":0,"numAtRisk":61}],"term":"Haematochezia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":2,"numAtRisk":92},{"groupId":"EG002","numAffected":1,"numAtRisk":61}],"term":"Haemorrhoids"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":17,"numAtRisk":30},{"groupId":"EG001","numAffected":49,"numAtRisk":92},{"groupId":"EG002","numAffected":14,"numAtRisk":61}],"term":"Nausea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":0,"numAtRisk":92},{"groupId":"EG002","numAffected":0,"numAtRisk":61}],"term":"Oesophagitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":3,"numAtRisk":92},{"groupId":"EG002","numAffected":1,"numAtRisk":61}],"term":"Oral pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":30},{"groupId":"EG001","numAffected":6,"numAtRisk":92},{"groupId":"EG002","numAffected":1,"numAtRisk":61}],"term":"Stomatitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":30},{"groupId":"EG001","numAffected":18,"numAtRisk":92},{"groupId":"EG002","numAffected":6,"numAtRisk":61}],"term":"Vomiting"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":30},{"groupId":"EG001","numAffected":11,"numAtRisk":92},{"groupId":"EG002","numAffected":3,"numAtRisk":61}],"term":"Asthenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":30},{"groupId":"EG001","numAffected":8,"numAtRisk":92},{"groupId":"EG002","numAffected":4,"numAtRisk":61}],"term":"Chills"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":30},{"groupId":"EG001","numAffected":37,"numAtRisk":92},{"groupId":"EG002","numAffected":12,"numAtRisk":61}],"term":"Fatigue"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":30},{"groupId":"EG001","numAffected":5,"numAtRisk":92},{"groupId":"EG002","numAffected":0,"numAtRisk":61}],"term":"Mucosal inflammation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":30},{"groupId":"EG001","numAffected":5,"numAtRisk":92},{"groupId":"EG002","numAffected":2,"numAtRisk":61}],"term":"Non-cardiac chest pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":30},{"groupId":"EG001","numAffected":15,"numAtRisk":92},{"groupId":"EG002","numAffected":7,"numAtRisk":61}],"term":"Oedema peripheral"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":30},{"groupId":"EG001","numAffected":22,"numAtRisk":92},{"groupId":"EG002","numAffected":6,"numAtRisk":61}],"term":"Pyrexia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Immune system disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":30},{"groupId":"EG001","numAffected":33,"numAtRisk":92},{"groupId":"EG002","numAffected":24,"numAtRisk":61}],"term":"Cytokine release syndrome"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Immune system disorders","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":30},{"groupId":"EG001","numAffected":9,"numAtRisk":92},{"groupId":"EG002","numAffected":2,"numAtRisk":61}],"term":"Hypogammaglobulinaemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":0,"numAtRisk":92},{"groupId":"EG002","numAffected":0,"numAtRisk":61}],"term":"COVID-19"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":30},{"groupId":"EG001","numAffected":2,"numAtRisk":92},{"groupId":"EG002","numAffected":0,"numAtRisk":61}],"term":"Oral candidiasis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":2,"numAtRisk":92},{"groupId":"EG002","numAffected":2,"numAtRisk":61}],"term":"Pneumonia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":30},{"groupId":"EG001","numAffected":6,"numAtRisk":92},{"groupId":"EG002","numAffected":1,"numAtRisk":61}],"term":"Urinary tract infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":30},{"groupId":"EG001","numAffected":4,"numAtRisk":92},{"groupId":"EG002","numAffected":0,"numAtRisk":61}],"term":"Fall"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":30},{"groupId":"EG001","numAffected":8,"numAtRisk":92},{"groupId":"EG002","numAffected":1,"numAtRisk":61}],"term":"Infusion related reaction"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA 26.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":30},{"groupId":"EG001","numAffected":6,"numAtRisk":92},{"groupId":"EG002","numAffected":0,"numAtRisk":61}],"term":"Vascular access site pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 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SAEs and Other AEs were assessed from first dose to 90 days after last dose of study therapy (Up to 16.5 months)."}