{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"67"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"40"}],"units":"Participants"}],"description":"Bioavailability (F) is defined as the percentage of the administered drug, that reaches the systemic circulation. A population PK model was developed for Mircera that adequately describes pediatric data: a 1-compartment model with first order absorption and elimination processes. The bioavailability (F) was estimated using all the data points listed under time frame using the population PK model.","groups":[{"description":"Mircera was administered subcutaneously once every 4 weeks.","id":"OG000","title":"Mircera"}],"paramType":"NUMBER","populationDescription":"PK population included all participants enrolled in the study.","reportingStatus":"POSTED","timeFrame":"Pre-dose at Week 1, 9, 17; Post-dose at Week 3, Week 19 and additional sample taken between 24 hours and 5 days at participant's convenience","title":"Bioavailability (F) of Mircera in Pediatric Participants Based on Population PK Model","type":"SECONDARY","unitOfMeasure":"percentage"}