{"classes":[{"categories":[{"measurements":[{"comment":"No data are available due to low event rate in the population.","groupId":"OG000","lowerLimit":"NA","upperLimit":"NA","value":"NA"},{"comment":"No data are available due to low event rate in the population.","groupId":"OG001","lowerLimit":"NA","upperLimit":"NA","value":"NA"},{"comment":"No data are available due to low event rate in the population.","groupId":"OG002","lowerLimit":"NA","upperLimit":"NA","value":"NA"},{"comment":"No data are available due to low event rate in the population.","groupId":"OG003","lowerLimit":"NA","upperLimit":"NA","value":"NA"},{"comment":"No data are available due to low event rate in the population.","groupId":"OG004","lowerLimit":"NA","upperLimit":"NA","value":"NA"},{"comment":"No data are available due to low event rate in the population.","groupId":"OG005","lowerLimit":"NA","upperLimit":"NA","value":"NA"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"4"},{"groupId":"OG004","value":"5"},{"groupId":"OG005","value":"3"}],"units":"Participants"}],"description":"TTR was defined as the time from the first dose of investigational product until the first documentation of objective response. Only participants who achieved an objective response were evaluated for TTR.\n\nTTR time in months: (date of the first observation of response - first dose of IP date +1)/30.4.","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants with RR MM and/or NHL received 80 mg AMG 397 QD2, as part of a 28-day treatment cycle.\n\nParticipants could receive AMG 397 until the participant became intolerant to the investigational product, signs and symptoms of clinical progression were evident as determined by the investigator, or the participant withdrew consent.","id":"OG000","title":"Part 1a: 80 mg AMG 397"},{"description":"Participants with RR MM and/or NHL received 160 mg AMG 397 QD2, as part of a 28-day treatment cycle.\n\nParticipants could receive AMG 397 until the participant became intolerant to the investigational product, signs and symptoms of clinical progression were evident as determined by the investigator, or the participant withdrew consent.","id":"OG001","title":"Part 1a: 160 mg AMG 397"},{"description":"Participants with RR MM received 320 mg AMG 397 QD2, as part of a 28-day treatment cycle.\n\nParticipants could receive AMG 397 until the participant became intolerant to the investigational product, signs and symptoms of clinical progression were evident as determined by the investigator, or the participant withdrew consent.","id":"OG002","title":"Part 1a: 320 mg AMG 397"},{"description":"Participants with RR AML received 80 mg AMG 397 QD2, as part of a 28-day treatment cycle.\n\nParticipants could receive AMG 397 until the participant became intolerant to the investigational product, signs and symptoms of clinical progression were evident as determined by the investigator, or the participant withdrew consent.","id":"OG003","title":"Part 1b: 80 mg AMG 397"},{"description":"Participants with RR AML received 160 mg AMG 397 QD2, as part of a 28-day treatment cycle.\n\nParticipants could receive AMG 397 until the participant became intolerant to the investigational product, signs and symptoms of clinical progression were evident as determined by the investigator, or the participant withdrew consent.","id":"OG004","title":"Part 1b: 160 mg AMG 397"},{"description":"Participants with RR AML received 320 mg AMG 397 QD2, as part of a 28-day treatment cycle.\n\nParticipants could receive AMG 397 until the participant became intolerant to the investigational product, signs and symptoms of clinical progression were evident as determined by the investigator, or the participant withdrew consent.","id":"OG005","title":"Part 1b: 320 mg AMG 397"}],"paramType":"MEDIAN","populationDescription":"Parts 2 and 3 were not initiated and did not enrol any participants, therefore results presented only included participants in part 1. Per the SAP, TTR was only to be calculated if the number of participants who experienced an event (objective response) was 10 or more in either part 1 or part 2.\n\nFAS: All participants who were enrolled and received at least 1 dose of AMG 397.","reportingStatus":"POSTED","timeFrame":"Up to end of study (a maximum of 48 weeks)","title":"Time to Response (TTR)","type":"SECONDARY","unitOfMeasure":"Months"}