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10"},{"categories":[{"measurements":[{"groupId":"OG002","lowerLimit":"50.0","upperLimit":"100.0","value":"100"},{"groupId":"OG003","lowerLimit":"50.0","upperLimit":"100.0","value":"100"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"Prior to Course 14"},{"categories":[{"measurements":[{"groupId":"OG002","lowerLimit":"50.0","upperLimit":"100.0","value":"100"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"Prior to Course 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30"},{"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"},{"groupId":"OG004","value":"0"}],"units":"Participants"}],"title":"Prior to Course 34"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"22.36","upperLimit":"100","value":"100"},{"groupId":"OG002","lowerLimit":"6.29","upperLimit":"72.87","value":"33.33"},{"groupId":"OG003","lowerLimit":"13.54","upperLimit":"98.30","value":"66.67"},{"groupId":"OG004","lowerLimit":"0","upperLimit":"52.71","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"4"}],"units":"Participants"}],"title":"End of Treatment"}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"12"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"5"}],"units":"Participants"}],"description":"Serial blood samples for anti-drug-antibodies (ADA) were to be collected prior to dosing on courses 1, 2, 3, and 4, then every third course (courses 7 and 10), and then every 4 courses (courses 14, 18, 22, 26, 30, 34) until the end of therapy visit and collected into serum tubes. Percentages of patients with positive anti-drug antibodies with a 95% Blyth-Still-Casella confidence interval are reported by time point.","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients with recurrent or refractory primary malignant CNS tumors received APX005M on day 1 of each 21-day course at 0.1 mg/kg for up to 36 courses or until disease progression, unacceptable toxicity, or death.","id":"OG000","title":"Stratum 1, Dose Level 1"},{"description":"Patients with recurrent or refractory primary malignant CNS tumors received APX005M on day 1 of each 21-day course at 0.3 mg/kg for up to 36 courses or until disease progression, unacceptable toxicity, or death.","id":"OG001","title":"Stratum 1, Dose Level 2"},{"description":"Patients with recurrent or refractory primary malignant CNS tumors received APX005M on day 1 of each 21-day course at 0.6 mg/kg for up to 36 courses or until disease progression, unacceptable toxicity, or death.","id":"OG002","title":"Stratum 1, Dose Level 3"},{"description":"Patients with newly diagnosed diffuse intrinsic pontine glioma (DIPG) received APX005M on day 1 of each 21-day course at 0.3 mg/kg for up to 36 courses or until disease progression, unacceptable toxicity, or death.","id":"OG003","title":"Stratum 2, Dose Level 2"},{"description":"Patients with newly diagnosed diffuse intrinsic pontine glioma (DIPG) received APX005M on day 1 of each 21-day course at 0.6 mg/kg for up to 36 courses or until disease progression, unacceptable toxicity, or death.","id":"OG004","title":"Stratum 2, Dose Level 3"}],"paramType":"NUMBER","populationDescription":"Ineligible patients were excluded from these analyses.","reportingStatus":"POSTED","timeFrame":"Prior to dosing on courses 1, 2, 3, 4, 7, 10, 14, 18, 22, 26, 30, and 34 and at the end of therapy (up to end of course 36)","title":"Incidence of Anti-APX005M Antibodies","type":"OTHER_PRE_SPECIFIED","unitOfMeasure":"percentage of patients with positive ADA"}