{"classes":[{"categories":[{"measurements":[{"comment":"Insufficient number of participants with events to calculate the upper confidence interval.","groupId":"OG000","lowerLimit":"5.22","upperLimit":"NA","value":"6.70"},{"groupId":"OG001","lowerLimit":"6.67","upperLimit":"44.62","value":"10.58"},{"groupId":"OG002","lowerLimit":"8.4","upperLimit":"22.7","value":"12.4"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"},{"groupId":"OG001","value":"11"},{"groupId":"OG002","value":"78"}],"units":"Participants"}],"description":"OS was defined as the time from the date of first treatment to the date of death due to any cause. Participants without documented death were censored at last alive date.","dispersionType":"95% Confidence Interval","groups":[{"description":"Duvelisib PO BID at a starting dose of 25 mg, with potential escalation on a per-participant basis to 50 mg and then 75 mg, based on the participant's response to and tolerance of therapy, in 28-day cycles.","id":"OG000","title":"Dose Optimization Phase: Cohort 1"},{"description":"Duvelisib 75 mg PO BID, administered in 28-day cycles.","id":"OG001","title":"Dose Optimization Phase: Cohort 2"},{"description":"Duvelisib PO BID at a starting dose of 75 mg for the first 2 cycles, followed by a mandatory reduction to 25 mg BID thereafter for those participants with CR, PR or SD, in 28-day cycles (dose determined in Optimization Phase).","id":"OG002","title":"Expansion Phase"}],"paramType":"MEDIAN","populationDescription":"Dose Optimization Efficacy Set: All participants who received at least one dose of study drug, completed at least one cycle of treatment, and had at least one scan to assess disease response after completion of one cycle of treatment. Modified Intent-to-treat (mITT): all participants who receive at least one dose of study drug. Here, 'Overall Number of Participants Analyzed' signifies those participants who were evaluable for this outcome measure.","reportingStatus":"POSTED","timeFrame":"Up to 70 months","title":"Overall Survival (OS)","type":"SECONDARY","unitOfMeasure":"month"}