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4 hours"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG001","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG002","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG003","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG004","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG005","lowerLimit":"5.0","upperLimit":"6.0","value":"5.00"},{"groupId":"OG006","lowerLimit":"5.0","upperLimit":"12.0","value":"5.00"},{"groupId":"OG007","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG008","lowerLimit":"5.0","upperLimit":"6.0","value":"5.00"},{"groupId":"OG009","lowerLimit":"5.0","upperLimit":"35.0","value":"6.50"},{"groupId":"OG010","lowerLimit":"5.0","upperLimit":"11.0","value":"8.00"},{"groupId":"OG011","lowerLimit":"1.7","upperLimit":"27.0","value":"5.00"},{"groupId":"OG012","lowerLimit":"1.7","upperLimit":"458.0","value":"1.70"},{"groupId":"OG013","lowerLimit":"1.7","upperLimit":"1.9","value":"1.70"},{"groupId":"OG014","lowerLimit":"1.7","upperLimit":"11.6","value":"1.70"},{"groupId":"OG015","lowerLimit":"1.7","upperLimit":"5.3","value":"1.70"},{"groupId":"OG016","lowerLimit":"1.4","upperLimit":"5.8","value":"1.70"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"6"},{"groupId":"OG007","value":"6"},{"groupId":"OG008","value":"4"},{"groupId":"OG009","value":"4"},{"groupId":"OG010","value":"4"},{"groupId":"OG011","value":"6"},{"groupId":"OG012","value":"6"},{"groupId":"OG013","value":"6"},{"groupId":"OG014","value":"11"},{"groupId":"OG015","value":"4"},{"groupId":"OG016","value":"9"}],"units":"Participants"}],"title":"Tumor necrosis factor-alpha: Cycle 1; 8 hours"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG001","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG002","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG003","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG004","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG005","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG006","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG007","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG008","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG009","lowerLimit":"5.0","upperLimit":"7.0","value":"5.00"},{"groupId":"OG010","lowerLimit":"5.0","upperLimit":"12.0","value":"5.00"},{"groupId":"OG011","lowerLimit":"1.7","upperLimit":"9.0","value":"5.00"},{"groupId":"OG012","lowerLimit":"1.7","upperLimit":"2.0","value":"1.70"},{"groupId":"OG013","lowerLimit":"1.7","upperLimit":"2.1","value":"1.70"},{"groupId":"OG014","lowerLimit":"1.7","upperLimit":"8.0","value":"2.45"},{"groupId":"OG015","lowerLimit":"1.7","upperLimit":"4.1","value":"2.90"},{"groupId":"OG016","lowerLimit":"1.7","upperLimit":"6.2","value":"1.70"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"5"},{"groupId":"OG007","value":"6"},{"groupId":"OG008","value":"4"},{"groupId":"OG009","value":"4"},{"groupId":"OG010","value":"4"},{"groupId":"OG011","value":"6"},{"groupId":"OG012","value":"6"},{"groupId":"OG013","value":"6"},{"groupId":"OG014","value":"12"},{"groupId":"OG015","value":"4"},{"groupId":"OG016","value":"9"}],"units":"Participants"}],"title":"Tumor necrosis factor-alpha: Cycle 1; 24 hours"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG001","lowerLimit":"5.0","upperLimit":"15.0","value":"5.00"},{"groupId":"OG002","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG003","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG004","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG005","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG006","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG007","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG008","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG009","lowerLimit":"5.0","upperLimit":"10.0","value":"5.00"},{"groupId":"OG010","lowerLimit":"5.0","upperLimit":"5.0","value":"5.00"},{"groupId":"OG011","lowerLimit":"1.7","upperLimit":"5.0","value":"5.00"},{"groupId":"OG012","lowerLimit":"1.7","upperLimit":"3.4","value":"1.70"},{"groupId":"OG013","lowerLimit":"1.7","upperLimit":"4.2","value":"1.70"},{"groupId":"OG014","lowerLimit":"1.7","upperLimit":"6.7","value":"1.70"},{"groupId":"OG015","lowerLimit":"1.7","upperLimit":"6.9","value":"3.85"},{"groupId":"OG016","lowerLimit":"1.7","upperLimit":"3.6","value":"1.70"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"1"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"5"},{"groupId":"OG007","value":"6"},{"groupId":"OG008","value":"4"},{"groupId":"OG009","value":"4"},{"groupId":"OG010","value":"4"},{"groupId":"OG011","value":"6"},{"groupId":"OG012","value":"6"},{"groupId":"OG013","value":"6"},{"groupId":"OG014","value":"12"},{"groupId":"OG015","value":"4"},{"groupId":"OG016","value":"8"}],"units":"Participants"}],"title":"Tumor necrosis factor-alpha: Cycle 1; 72 hours"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"6"},{"groupId":"OG007","value":"6"},{"groupId":"OG008","value":"4"},{"groupId":"OG009","value":"4"},{"groupId":"OG010","value":"4"},{"groupId":"OG011","value":"6"},{"groupId":"OG012","value":"6"},{"groupId":"OG013","value":"7"},{"groupId":"OG014","value":"13"},{"groupId":"OG015","value":"4"},{"groupId":"OG016","value":"9"}],"units":"Participants"}],"description":"The concentration of Interleukin-2, Interleukin-6, Interferon-gamma and tumor necrosis factor-alpha were measured in this outcome measure. Cycle = C.","dispersionType":"Full Range","groups":[{"description":"Participants with relapsed/refractory advanced multiple myeloma (MM) received PF-06863135 at a dose of 0.1 microgram/kilogram (mcg/kg) as an intravenous (IV) infusion for 2 hours on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG000","title":"Part 1: PF-06863135 0.1 mcg/kg IV"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 0.3 mcg/kg as an IV infusion for 2 hours on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG001","title":"Part 1: PF-06863135 0.3 mcg/kg IV"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 1 mcg/kg as an IV infusion for 2 hours on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG002","title":"Part 1: PF-06863135 1 mcg/kg IV"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 3 mcg/kg as an IV infusion for 2 hours on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG003","title":"Part 1: PF-06863135 3 mcg/kg IV"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 10 mcg/kg as an IV infusion for 2 hours on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG004","title":"Part 1: PF-06863135 10 mcg/kg IV"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 30 mcg/kg as an IV infusion for 2 hours on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG005","title":"Part 1: PF-06863135 30 mcg/kg IV"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 50 mcg/kg as an IV infusion for 2 hours on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG006","title":"Part 1: PF-06863135 50 mcg/kg IV"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 80 mcg/kg as a subcutaneous (SC) injection on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG007","title":"Part 1: PF-06863135 80 mcg/kg SC"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 130 mcg/kg as a SC injection on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG008","title":"Part 1: PF-06863135 130 mcg/kg SC"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 215 mcg/kg as a SC injection on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG009","title":"Part 1: PF-06863135 215 mcg/kg SC"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 360 mcg/kg as a SC injection on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG010","title":"Part 1: PF-06863135 360 mcg/kg SC"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 600 mcg/kg as a SC injection on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG011","title":"Part 1: PF-06863135 600 mcg/kg SC"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a dose of 1000 mcg/kg as a SC injection on Day 1, 8 and 15 of each 21-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG012","title":"Part 1: PF-06863135 1000 mcg/kg SC"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a priming dose of 600 mcg/kg as a SC injection, on Day 1 of Cycle 0. Participants received maintenance dose of 1000 mcg/kg as a SC injection every week (Q1W) on Day 1, 8, 15 and 22 of each 28-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG013","title":"Part 1.1: PF-06863135 Priming Cohort Q1W SC"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a priming dose of 600 mcg/kg as a SC injection, on Day 1 of Cycle 0. Participants received maintenance dose of 1000 mcg/kg as a SC injection every 2 weeks (Q2W) on Day 1 and 15 of each 28-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG014","title":"Part 1.1: PF-06863135 Priming Cohort Q2W SC"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a priming dose of 32 mcg as a SC injection, on Day 1 of Cycle 0. Participants received maintenance dose of 44 mcg as a SC injection Q1W on Day 1, 8, 15 and 22 along with lenalidomide at dose of 15 mg, orally, daily on Days 1-21 of each 28-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG015","title":"Part 1C: PF-06863135 + Lenalidomide SC"},{"description":"Participants with relapsed/refractory advanced MM received PF-06863135 at a priming dose of 32 mcg as a SC injection, on Day 1 of Cycle 0. Participants received maintenance dose of 44 mcg as a SC injection Q1W on Day 1, 8, 15 and 22 along with pomalidomide at dose of 4 mg, orally, daily on Days 1-21 of each 28-day cycle. Participants received treatment until disease progression, unacceptable toxicity, withdrawal of consent, death, or study termination, whichever occurred first.","id":"OG016","title":"Part 1D: PF-06863135 + Pomalidomide SC"}],"paramType":"MEDIAN","populationDescription":"The Pharmacodynamic (PD)/Biomarker analysis set included all enrolled participants with at least 1 of the PD/Biomarkers evaluated at pre- and/or post-dose. Here, \"Number Analyzed\" signifies participants evaluable for specified rows.","reportingStatus":"POSTED","timeFrame":"Part 1: C1 (0, 2, 4 & 8 hours [h] post dose on Day [D] 1, 24h post dose on D2, 72h post dose on D3); Part 1.1, 1C & 1D: C0 (0, 2, 4 & 8h post dose on D1, 24h post dose on D2); C1 (0, 2, 4 & 8h post dose on D1, 24h post dose on D2, 72h post dose on D3)","title":"Part 1: Concentration of Soluble Cytokines in Serum","type":"SECONDARY","unitOfMeasure":"Picogram per milliliter"}