{"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"groups":[{"description":"Participants were administered azacitidine 75 mg/m\\^2 IV or SC injection on Days 1 to 5, Days 8 and 9, in 28-day treatment cycles until disease progression or unacceptable toxicity or up to a maximum of 63 cycles.","id":"BG000","title":"Azacitidine 75 mg/m^2"},{"description":"Participants were administered azacitidine 75 mg/m\\^2 IV or SC injection on Days 1 to 5, Days 8 and 9 and pevonedistat 20 mg/m\\^2 IV infusion, on Days 1, 3, and 5 in 28-day treatment cycles until disease progression or unacceptable toxicity or up to a maximum of 63 cycles.","id":"BG001","title":"Pevonedistat 20 mg/m^2 + Azacitidine 75 mg/m^2"},{"description":"Total of all reporting groups","id":"BG002","title":"Total"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"8.22","value":"73.0"},{"groupId":"BG001","spread":"7.65","value":"73.0"},{"groupId":"BG002","spread":"7.93","value":"73"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","title":"Age, Continuous","unitOfMeasure":"years"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"85"},{"groupId":"BG001","value":"95"},{"groupId":"BG002","value":"180"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"142"},{"groupId":"BG001","value":"132"},{"groupId":"BG002","value":"274"}],"title":"Male"}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"26"},{"groupId":"BG001","value":"31"},{"groupId":"BG002","value":"57"}],"title":"Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"188"},{"groupId":"BG001","value":"189"},{"groupId":"BG002","value":"377"}],"title":"Not Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"13"},{"groupId":"BG001","value":"7"},{"groupId":"BG002","value":"20"}],"title":"Unknown or Not Reported"}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Ethnicity (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"4"},{"groupId":"BG002","value":"6"}],"title":"American Indian or Alaska Native"},{"measurements":[{"groupId":"BG000","value":"20"},{"groupId":"BG001","value":"31"},{"groupId":"BG002","value":"51"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"}],"title":"Native Hawaiian or Other Pacific Islander"},{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"2"},{"groupId":"BG002","value":"3"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"189"},{"groupId":"BG001","value":"180"},{"groupId":"BG002","value":"369"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"}],"title":"More than one race"},{"measurements":[{"groupId":"BG000","value":"15"},{"groupId":"BG001","value":"10"},{"groupId":"BG002","value":"25"}],"title":"Unknown or Not Reported"}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"3"},{"groupId":"BG001","value":"4"},{"groupId":"BG002","value":"7"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Australia"},{"categories":[{"measurements":[{"groupId":"BG000","value":"8"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"11"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Belgium"},{"categories":[{"measurements":[{"groupId":"BG000","value":"10"},{"groupId":"BG001","value":"18"},{"groupId":"BG002","value":"28"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Brazil"},{"categories":[{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"2"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"China"},{"categories":[{"measurements":[{"groupId":"BG000","value":"10"},{"groupId":"BG001","value":"6"},{"groupId":"BG002","value":"16"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Czech Republic"},{"categories":[{"measurements":[{"groupId":"BG000","value":"6"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"9"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Germany"},{"categories":[{"measurements":[{"groupId":"BG000","value":"26"},{"groupId":"BG001","value":"23"},{"groupId":"BG002","value":"49"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Spain"},{"categories":[{"measurements":[{"groupId":"BG000","value":"13"},{"groupId":"BG001","value":"8"},{"groupId":"BG002","value":"21"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"France"},{"categories":[{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"4"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"United Kingdom"},{"categories":[{"measurements":[{"groupId":"BG000","value":"30"},{"groupId":"BG001","value":"28"},{"groupId":"BG002","value":"58"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Greece"},{"categories":[{"measurements":[{"groupId":"BG000","value":"6"},{"groupId":"BG001","value":"6"},{"groupId":"BG002","value":"12"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Israel"},{"categories":[{"measurements":[{"groupId":"BG000","value":"14"},{"groupId":"BG001","value":"9"},{"groupId":"BG002","value":"23"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Italy"},{"categories":[{"measurements":[{"groupId":"BG000","value":"12"},{"groupId":"BG001","value":"26"},{"groupId":"BG002","value":"38"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Japan"},{"categories":[{"measurements":[{"groupId":"BG000","value":"4"},{"groupId":"BG001","value":"2"},{"groupId":"BG002","value":"6"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Korea, Republic of"},{"categories":[{"measurements":[{"groupId":"BG000","value":"11"},{"groupId":"BG001","value":"10"},{"groupId":"BG002","value":"21"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Poland"},{"categories":[{"measurements":[{"groupId":"BG000","value":"22"},{"groupId":"BG001","value":"12"},{"groupId":"BG002","value":"34"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Russia"},{"categories":[{"measurements":[{"groupId":"BG000","value":"5"},{"groupId":"BG001","value":"5"},{"groupId":"BG002","value":"10"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Turkey"},{"categories":[{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"7"},{"groupId":"BG002","value":"9"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Canada"},{"categories":[{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"5"},{"groupId":"BG002","value":"7"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"Mexico"},{"categories":[{"measurements":[{"groupId":"BG000","value":"40"},{"groupId":"BG001","value":"49"},{"groupId":"BG002","value":"89"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"227"},{"groupId":"BG002","value":"454"}],"units":"Participants"}],"title":"United States of America"}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Region of Enrollment","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"9.439","value":"167.59"},{"groupId":"BG001","spread":"10.098","value":"166.31"},{"groupId":"BG002","spread":"9.783","value":"166.95"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"225"},{"groupId":"BG001","value":"223"},{"groupId":"BG002","value":"448"}],"units":"Participants"}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","populationDescription":"ITT Population included all participants who were randomized. Number analyzed is the number of participants with data available for height at Baseline.","title":"Height","unitOfMeasure":"centimeter (cm)"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"16.143","value":"77.65"},{"groupId":"BG001","spread":"15.996","value":"75.82"},{"groupId":"BG002","spread":"16.078","value":"76.73"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"227"},{"groupId":"BG001","value":"226"},{"groupId":"BG002","value":"453"}],"units":"Participants"}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","populationDescription":"ITT Population included all participants who were randomized. Number analyzed is the number of participants with data available for weight at Baseline.","title":"Weight","unitOfMeasure":"kilogram (kg)"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"0.228","value":"1.89"},{"groupId":"BG001","spread":"0.233","value":"1.86"},{"groupId":"BG002","spread":"0.231","value":"1.88"}]}],"denoms":[{"counts":[{"groupId":"BG000","value":"225"},{"groupId":"BG001","value":"223"},{"groupId":"BG002","value":"448"}],"units":"Participants"}]}],"description":"Body surface area is defined as \\[height (cm) × weight (kg) / 3600\\]\\^1/2","dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","populationDescription":"ITT Population included all participants who were randomized. Number analyzed is the number of participants with data available for body surface area at Baseline.","title":"Body Surface Area","unitOfMeasure":"meter square (m^2)"}],"populationDescription":"ITT Population included all participants who were randomized."}